ID   J2Q960_9CAUL            Unreviewed;       350 AA.
AC   J2Q960;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE            EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN   ORFNames=PMI01_00958 {ECO:0000313|EMBL:EJL36557.1};
OS   Caulobacter sp. AP07.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=1144304 {ECO:0000313|EMBL:EJL36557.1, ECO:0000313|Proteomes:UP000007300};
RN   [1] {ECO:0000313|EMBL:EJL36557.1, ECO:0000313|Proteomes:UP000007300}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AP07 {ECO:0000313|EMBL:EJL36557.1,
RC   ECO:0000313|Proteomes:UP000007300};
RX   PubMed=23045501; DOI=10.1128/JB.01243-12;
RA   Brown S.D., Utturkar S.M., Klingeman D.M., Johnson C.M., Martin S.L.,
RA   Land M.L., Lu T.Y., Schadt C.W., Doktycz M.J., Pelletier D.A.;
RT   "Twenty-one genome sequences from Pseudomonas species and 19 genome
RT   sequences from diverse bacteria isolated from the rhizosphere and
RT   endosphere of Populus deltoides.";
RL   J. Bacteriol. 194:5991-5993(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC         methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC         ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00001709};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJL36557.1}.
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DR   EMBL; AKKF01000060; EJL36557.1; -; Genomic_DNA.
DR   RefSeq; WP_007663766.1; NZ_AKKF01000060.1.
DR   AlphaFoldDB; J2Q960; -.
DR   PATRIC; fig|1144304.3.peg.918; -.
DR   Proteomes; UP000007300; Unassembled WGS sequence.
DR   GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR   CDD; cd06558; crotonase-like; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR045004; ECH_dom.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR032259; HIBYL-CoA-H.
DR   PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR   Pfam; PF16113; ECH_2; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT   DOMAIN          15..337
FT                   /note="Enoyl-CoA hydratase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF16113"
SQ   SEQUENCE   350 AA;  38569 MW;  578BB832514788AD CRC64;
     MNDQPEVLVR VQKNVGRLTL NRPQALHALT QTMCEIMIGA LLDWQEDPEI YMVIIDHAGE
     RGFCAGGDIR MLAHSGAGDG KEARAFFHTE YQLNHLLFTY ETPVVAVMDG VVMGGGVGIS
     MPAHYRIATE RTTYAMPETG IGLFPDVGGG WYLPRLPGKA GLWLALTGAR IKGADCLRLG
     IATHFVEFGA VEGLKKAIVA DPRRIDDTLK KYRADAGKAP LVSTELDLNR LFVGDSVEQI
     FEFLEADSSD WGKAQLAVLK TKSPQTLKVA FRQLETGAAL TDFADNMVME YRIGARVVQR
     HDFIEGVRAV IIDKDNAPRW DPAKLEDVSD AMLDEIFAPL PSDQEWTPLT
//