ID J2TCT4_9BURK Unreviewed; 643 AA.
AC J2TCT4;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Family 3 adenylate cyclase {ECO:0000313|EMBL:EJL76012.1};
GN ORFNames=PMI12_02506 {ECO:0000313|EMBL:EJL76012.1};
OS Variovorax sp. CF313.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Variovorax.
OX NCBI_TaxID=1144315 {ECO:0000313|EMBL:EJL76012.1, ECO:0000313|Proteomes:UP000007277};
RN [1] {ECO:0000313|EMBL:EJL76012.1, ECO:0000313|Proteomes:UP000007277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CF313 {ECO:0000313|EMBL:EJL76012.1,
RC ECO:0000313|Proteomes:UP000007277};
RX PubMed=23045501; DOI=10.1128/JB.01243-12;
RA Brown S.D., Utturkar S.M., Klingeman D.M., Johnson C.M., Martin S.L.,
RA Land M.L., Lu T.Y., Schadt C.W., Doktycz M.J., Pelletier D.A.;
RT "Twenty-one genome sequences from Pseudomonas species and 19 genome
RT sequences from diverse bacteria isolated from the rhizosphere and
RT endosphere of Populus deltoides.";
RL J. Bacteriol. 194:5991-5993(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJL76012.1}.
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DR EMBL; AKIW01000038; EJL76012.1; -; Genomic_DNA.
DR RefSeq; WP_007832605.1; NZ_AKIW01000038.1.
DR AlphaFoldDB; J2TCT4; -.
DR PATRIC; fig|1144315.3.peg.2498; -.
DR Proteomes; UP000007277; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 37..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 462..594
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 643 AA; 70113 MW; 25C337061D40AD2E CRC64;
MNKKSSGNPE AAGKPSIETA AAPAAPPGRS RRFRVDVGTI VSAVALTQSL LLVSLGYWGS
QRLVSRIGVS AHKANHHRTE DKVLAFLQKA ESVVNAVGTA PSLRPAGEHA ERTAELLWTL
LQQSPELDSI YVSNEKGQML MALRYPVPAM RHIERGAGFT TETWQYMLPQ DAEADVQQRF
ATQRLAAFRS SYDPTQRGWY VQARKAQGPV WTQPYVFAAA QELGVTYALP SQRSYADSAA
QAMVVAGDVS LGRLSEFVRQ FSNDGYGDSA LLSADARVLA RSDMPGVLHQ LEPPAGVLGA
LYANTVIGGT ADSGSNKKFS FTYEGRRYLV QASRIPSTGW QLVSWVPEDM LLGELNRAVL
WGLLLALAFL AIALFISLKL SKLVTSPVEN LSHIARSIGL LELDNLPREP SRVLEIQHLD
QALDDSARSL KAFSKFVPVD VINQLIDEGH ALAPSGSSRR VTVMFTDVEG FTSISESLDT
DVLVGMLTEY FNLAAGVFAR HGGVVDKFIG DGIMVLWGAP SDLKDAEYQA CVAALELHVE
MDELNRKWHE QGLPRFRTRI GIHTGMVIAG VLGSNDRLSY TAFGDAINVA SRIEGINKQL
GTQTLISEAT FAGLGGRLHA RRIEELVELR GRQTRMVLYE LTA
//
