ID J3D7X8_9BURK Unreviewed; 882 AA.
AC J3D7X8;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=PMI16_03173 {ECO:0000313|EMBL:EJL86431.1};
OS Herbaspirillum sp. CF444.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Herbaspirillum.
OX NCBI_TaxID=1144319 {ECO:0000313|EMBL:EJL86431.1, ECO:0000313|Proteomes:UP000007296};
RN [1] {ECO:0000313|EMBL:EJL86431.1, ECO:0000313|Proteomes:UP000007296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CF444 {ECO:0000313|EMBL:EJL86431.1,
RC ECO:0000313|Proteomes:UP000007296};
RX PubMed=23045501; DOI=10.1128/JB.01243-12;
RA Brown S.D., Utturkar S.M., Klingeman D.M., Johnson C.M., Martin S.L.,
RA Land M.L., Lu T.Y., Schadt C.W., Doktycz M.J., Pelletier D.A.;
RT "Twenty-one genome sequences from Pseudomonas species and 19 genome
RT sequences from diverse bacteria isolated from the rhizosphere and
RT endosphere of Populus deltoides.";
RL J. Bacteriol. 194:5991-5993(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJL86431.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AKJW01000067; EJL86431.1; -; Genomic_DNA.
DR RefSeq; WP_007881181.1; NZ_AKJW01000067.1.
DR AlphaFoldDB; J3D7X8; -.
DR STRING; 1144319.PMI16_03173; -.
DR PATRIC; fig|1144319.3.peg.3223; -.
DR eggNOG; COG0550; Bacteria.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000007296; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR025589; Toprim_C_rpt.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR Pfam; PF13342; Toprim_Crpt; 2.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:EJL86431.1};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 3..136
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT REGION 825..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 867..882
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 882 AA; 98266 MW; 50476B1898D37BE0 CRC64;
MSKTLIIAEK PSVANDIAKT LGGFTKHDEY FESDEYVLSS AVGHLLEIAV PEEYDVKRGK
WTFTHLPMIP PHFALNPIAK TESRLKALNK LIKRKDVTGL INACDAGREG ELIFRLIAQY
TKAKQPVQRL WLQSMTPGAI RDGFANLRKD EDMLPLADAA RCRSEADWLI GINGTRAMTA
FNSKEGGFYL TTVGRVQTPT LSIVVEREEK IKKFVPRDYW EVRGEFVCAA GIYEGRWLDK
MHKKDENDPE KRPERLWSKA AAESIVAACR GKIGTVTEES KPTTQMAPGL FDLTSLQREA
NSRFGFSAKN TLGLAQALYE KHKVLTYPRT DSRHLPEDYL QTVKETMESL SENNNYHQFS
KQILKQGWVK PNKRIFDNTK ISDHFAIIPT TQVPKNLSEP EQKLYDLVTR RFMAVFFPAA
EFQVTTRFTE VSGHQFKTEG KVMTNPGWLA IYGKDIVDEK DENSGTLVAV AKDEKVKTDK
VTANGLVTKP PARYTEATLL SAMEGAGKLI DSDELREAMA GKGLGTPATR AAIIEGLLNE
KYLLREGREM MPTAKAFQLM TLLHGLGVDE LTEPELTGEW EQKLAQMERG KISREEFMRE
IAQMTQIIVK RAKEYDNDTI PGDYATLKTP CPNCGSVVKE NYRRFACTKC EFSMSKTPAG
RQFEIPEVEE LLANRTIGPL QGFRSKMGRP FAAILKISRD NEINNYKLEF DFGQNDGEGE
GGEPVDFSEQ TPLGPCPKCG SGVYEMGLAY VCEKQVAKPK ACDFRSGRII LQQEILPEQM
AKLLNEGKTD LLPGFISQRT RRPFKAFLTR GKDGKISFEF EERKAKAPAK GKAAAATAEG
DDAETTAKAK PAAAAKKPAV ARKPAAAKKP AVKKAAPKKA AA
//
