ID J3HJZ9_9BURK Unreviewed; 3362 AA.
AC J3HJZ9;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Non-ribosomal peptide synthase/amino acid adenylation enzyme {ECO:0000313|EMBL:EJM97622.1};
GN ORFNames=PMI40_04290 {ECO:0000313|EMBL:EJM97622.1};
OS Herbaspirillum sp. YR522.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Herbaspirillum.
OX NCBI_TaxID=1144342 {ECO:0000313|EMBL:EJM97622.1, ECO:0000313|Proteomes:UP000007507};
RN [1] {ECO:0000313|EMBL:EJM97622.1, ECO:0000313|Proteomes:UP000007507}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YR522 {ECO:0000313|EMBL:EJM97622.1,
RC ECO:0000313|Proteomes:UP000007507};
RX PubMed=23045501; DOI=10.1128/JB.01243-12;
RA Brown S.D., Utturkar S.M., Klingeman D.M., Johnson C.M., Martin S.L.,
RA Land M.L., Lu T.Y., Schadt C.W., Doktycz M.J., Pelletier D.A.;
RT "Twenty-one genome sequences from Pseudomonas species and 19 genome
RT sequences from diverse bacteria isolated from the rhizosphere and
RT endosphere of Populus deltoides.";
RL J. Bacteriol. 194:5991-5993(2012).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJM97622.1}.
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DR EMBL; AKJA01000136; EJM97622.1; -; Genomic_DNA.
DR RefSeq; WP_008118945.1; NZ_AKJA01000136.1.
DR STRING; 1144342.PMI40_04290; -.
DR PATRIC; fig|1144342.3.peg.3913; -.
DR eggNOG; COG1020; Bacteria.
DR OrthoDB; 8824838at2; -.
DR Proteomes; UP000007507; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd17649; A_NRPS_PvdJ-like; 1.
DR CDD; cd19543; DCL_NRPS; 1.
DR CDD; cd19534; E_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 4.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 4.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 8.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007507}.
FT DOMAIN 994..1068
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2076..2150
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 3362 AA; 367091 MW; D91AAB1422C996E1 CRC64;
MNEKNHQLLA LLQRDQQEQG GAGGELSGHA MAGPAPLSFS QQQLWALQQL EPGQTAYNLT
RAFRLRGPLV HAALQAAFDA LVARHASLRT RFVEQDGIAS QVVEPVAPMA LEVIDCRHHA
AAGHAQLIAA QIDAAAAHVF DLTQARLLLV RLLQLGDDDH LLVIGMHHIV SDAWSNPIVA
HDLARAYRQA LQGQAPVLPA LPVQYADYAR WQRERLQGPW LQQELDYWQE KLGAQVSPLN
LPLDRPRPGT ASFAGAAHAF VLDQALANGL RQFCRDERCT PFVVLLAGWQ ALLRHYCGQD
DFTLGIPQAG RQRPELQEMV GFFVTTQVMR ARLQPRMSMR ELCRQVRGDT LDALSHTELP
FELLLERYPA ERGLARHPLF QTMFGLQVID GAATLELDGI SATTLDIATR SAKFDVALDV
KIINGRVTAR LEYSTDLFEA ATMARIARHY QALLRQMVAD PQQAIGELQL LAPDEREALL
QSSENRQGHG TGDVLALIEA QVARSGSRPA LRVPHTGQAL GYAQLNDQAN ALAHWLMAQG
VGCDDRVGVC MERSQDMVVA LLAIMKAGAA YVPMDPDHPP QRLQYFIDDS RTRLLLTHAP
VWAQLQGLAP GCAPVDVGTL DLSAQPRHNP GLALHPEQLA YVIYTSGSTG QPKGAANRHA
SLWNRLAWMQ QAYQLESSDR VLQKTPFGFD VSVWEFFWPL MTGAELVMAA PGEHRDPARL
AALIDSAGIT TLHFVPSMLQ AFVNDGDGVR CPSLRRVICS GEALPMELQQ QAQRQLPHAR
LINLYGPTEA AIDVTHWTCV VGDTGSSVPI GRPISATQAF VLDDALQLVP PGVAGELYLG
GINLGRGYLG KPGLTAERFV ASPFADDGQR LYRTGDLVRW REDGQIMYLG RLDHQVKIRG
LRIELGEIEA ALLAQPGVRE AVVVAADGQL LVAYVAGEGI DERAVRAALA QRLPQYMVPA
VMVQLPRLPL STNGKIDRKA LPAVERGSEA AYAEPVGEIE QRLAAIWQEV LGIERVGRQD
NFFALGGDSI LSLQIIARLR RAGWKVTPRQ VFDRQTVAHL AAVAVAIDLP AGSGADAPRA
AGPDLSLLAQ PLTAQQQALL PVGMDQLEAV YPLSPMQTGM LFHSVYEAGS AAYVNQLRID
IDGALDPERF GAAWQAMQQR HGVLRTGFLA DSTPPLQWVA PAAALPLRQL DVRAVDDCAT
TLDGIAEAEL ALGFDLRRPP LQRLVLVRSG QRRHHFIWTI HHLLLDGWST SQLLGEVVRH
YHGVDTAAPA GSYRHYIGWL QQQDAEQPRR FWQQALAPLT APTYLQQAFI APAAGETGFG
EYKVVLPVPQ AEALNRFARE HRVTLNTLFQ AAWGLLLQRY TGHGAVCFGA TVAGRPDELE
GAQQLLGLFI NTLPVIVPAS HDQPVATWLQ ALQQHNLAAR AVQHTPLYDI QRWHAHLGQS
LFDSILVFEN YPIDSALRSG SAADISFRRT HSREQTNYPM TVGVAPGDGV GAGLHIGWRY
DRSRFGDAAV VQIARHLQYC LEQIVQSGTR PVGALAMLDP EQQAALLALG RVEDSQFVPE
PIHVLFARQA QRNPAAEAVV MGERSLSYGE VEARANRLAS QLRRQGFDGA AGEQRIGVAL
PRSPEMIVVL LAILKAGAGY VPIDLETPSD RLAGMLDDAG VTLMISQREP LARWPALAAR
PALRLLAIDE LDLAHGQAQA SAVDVVPEQL AYVIYTSGST GRAKGVEVAH GPLSMHIQAT
AALYEMGPQS RELHFLSFAF DGAHERWMTV LSVGGTLVLR DSELWTPEQT AAALHRHRIT
HAGFPPVYLK QLADWVERSG NPPPVFLYSF GGEAMPRDTF EQVRRALRPQ RLINGYGPTE
TVVTPLVWKV DAGQACDVPY APIGRPVGQR TAMILDDRLQ LLPHGVAGEL YIGGSGLARG
YLDRPGLTAG AFVADPFGAP GARMYRTGDL ARWRDDGQIA YLGRIDHQVK IKGFRIELGE
VEAALLAQPG VRQAVAVVRP VAGVDRLLAY VAAHHDSAPD PVALQRALAA SLPGYMVPGK
IGLLPALPLN ANGKIDRKAL PDETRFEHEG TSLGEPPEGP LEALIAHSWQ AVLGVPAVGR
HDNFFELGGD SILSLQIIAR LRQDGWKLTP KQIFEQQTVA ALAQVAEAVE ALPDRAPLEG
DDASSGPVPL LPIQAQFLAT DIARRQHWNQ AIMLRSAAPI DRQAMQQAVA AIVDHHDALR
MHYVQQGDGT WVQSYGARAA GEAASSCWHA QVDSAAQMAQ FCARAQRSLD LQHGPLLRAA
TMALADGSWR LLLVVHHLVV DGVSWRVLLE DLQGAYAQCL AGRPIALPPK TASYREWGQA
LQAFAATATD ELPFWRTLAE VPAKLPCDHP QAPLLAADQA RLACRLDAAT TQALLKQAPA
AYRTQINDLL LAALGRALGQ WSGQAHMLIT LEGHGREQLD EAGDGLDVSR TVGWFTSMLP
VALPTAGDWR TQIGAVKETL RAIPRKGIGF GLLRHWGSDA QREVLANIPT PSLAFNYLGQ
FDGNFRDGGP WQPAPESPGA SRDDAAPMAC DLSINGQVVG GELRMEVTYS RRRFDAATID
GFVQRLQAAL QDMVDHCCAG NSGVTPSDFP LAQLTQPQLD RLQHELGCAA AQIEDIYPTT
PMQQRMLRHL SEQPWSAANV VQLDTTSKTI DVARFCDAWR SVLQRHPILR TGFAWLDSLR
SVQVVMREAS LPVTVLDWRG RADANVRDEW QALCRHEHQR GFDARHAPLM RFVIVQRDDG
YQLLWTWHHI LLDGWSMSQL LGEVFSLVEG QPLARQALDF RHYMAWLAQQ SSVDDQAFWR
ARFAQCGPGG PAGLLCRSAA VHDMAAELTP SPGSGAASAY ATEYLQLDLE HTRLLQGFGA
SCKVTLNTLV QAAWSVVLHD MTGAADVVFG VTVSGRSVDF PGVERIMGMC INVLPLIQHL
DGGQDVASWL AQLQSHNLAL RQREHVALDE IERWSARPGQ ALFDTLVIFE NFPVDESLKK
GVGRSLAFET IRSRGATEHP LTLVVLPGAS LRFQFEYDGA RLPQALVQQL AQRLADGLGR
LPTQDTLQGL LRGGGGLMPS ALPAIPPAPV LVHHPASRPP DPQGPVLVCF PARMSNPQEY
AGLATALGQA HPVWQLVCPP HERWRWASMD VPAMAARYAA AIGGQFAGRT CRFIGWSVGG
LLAIETARQL QAQAALTVEW IGLVDSSDFS LLRAQLEQMP LPPASALAPH EQTLHQWLQR
SSMAGLWHAL LAQMTPRQRA YFLLDIVARL GQRLPTDAPG QPGAEAALWE RIRCLRLGLD
AQVTLSTPIH VWQAGQRETG QAPTDWTRHT PRLASLTVVE GADHLSILES AGWYRGVRDL
LG
//
