ID J3HMG2_9BURK Unreviewed; 1938 AA.
AC J3HMG2;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Large extracellular alpha-helical protein {ECO:0000313|EMBL:EJM99807.1};
GN ORFNames=PMI40_03693 {ECO:0000313|EMBL:EJM99807.1};
OS Herbaspirillum sp. YR522.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Herbaspirillum.
OX NCBI_TaxID=1144342 {ECO:0000313|EMBL:EJM99807.1, ECO:0000313|Proteomes:UP000007507};
RN [1] {ECO:0000313|EMBL:EJM99807.1, ECO:0000313|Proteomes:UP000007507}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YR522 {ECO:0000313|EMBL:EJM99807.1,
RC ECO:0000313|Proteomes:UP000007507};
RX PubMed=23045501; DOI=10.1128/JB.01243-12;
RA Brown S.D., Utturkar S.M., Klingeman D.M., Johnson C.M., Martin S.L.,
RA Land M.L., Lu T.Y., Schadt C.W., Doktycz M.J., Pelletier D.A.;
RT "Twenty-one genome sequences from Pseudomonas species and 19 genome
RT sequences from diverse bacteria isolated from the rhizosphere and
RT endosphere of Populus deltoides.";
RL J. Bacteriol. 194:5991-5993(2012).
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJM99807.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AKJA01000120; EJM99807.1; -; Genomic_DNA.
DR RefSeq; WP_008117868.1; NZ_AKJA01000120.1.
DR STRING; 1144342.PMI40_03693; -.
DR PATRIC; fig|1144342.3.peg.3424; -.
DR eggNOG; COG2373; Bacteria.
DR OrthoDB; 9767116at2; -.
DR Proteomes; UP000007507; Unassembled WGS sequence.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 2.60.40.3710; -; 1.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF01835; MG2; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007507}.
FT DOMAIN 1025..1204
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 1262..1352
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT REGION 722..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1938 AA; 209601 MW; B41297C8C34011B6 CRC64;
MNTTGGGGAI EKQWLRAALA AVAAVVLAWT VAPVADAATA SVTSVSPQGE VARIRQVRVR
FSESMVKFGD PKAAAPFDVD CPVAGTPRWA DDKNWVYDFE RDLPPGTSCA LTLRGAARSA
AGNAVAGKRR YQFSTGGPAV SRTRPEYGQL ITEDQAFVLY QNGAAVESSV LQHLYCEAEG
IHERIAVKLL PAQQRQALLK SFDEKVDPAT ITIVQCQQRL PNDAAVRLVW DRGIAAANAP
AITTTQPQVF KYTVRSEFSA SFSCQRENAN AACSPILPVT LSFSSPVPRK LAEQVVLDGG
SGKIKPSFSQ DERGDTVNAV TFKPPFVEKS AFTLHLPAGF KDEDGRVLAN ASAFPLKSAM
ADFPPLAKFP AAPFGIIELN ADPALPVTLR RVEASLQVRG TDGRAMPGKV ADLKVQDDRG
IITWLSRLNR YHEKWGNPKQ VDSRGISLLE REPGVKTLNL PQPKEAVEGS WPFEVVGIPL
ADPGFYVVEL ASHKLGASLL GKPQPMYVRT SALVTNLSVH VKLGRENGAV WVTRLDDAKP
VANADVRVSS CTGQSLWQGK TNAAGVAMLP ALDDPCLNLP YEEGRIGGLF VSARKSDEKG
RADMAFALTS WNDGIESWRF NLPTDTSRQA TTRATTIFDR TLLRAGETVS MKHLMRVESM
QGFGLMRAQD LPTRVRITHQ GSGQQFQFPL SWRAGKSAET VFALPKQAKL GAYDVVLDQG
RADPNRQDAA NGDADGDGGD GDGGQHAFYT GSFRVEEFRL PLMQGRMSAP KGPQVAIKEL
PLQLQLNYLN GGGAAGQQVR VSSLLRARSV SFAGYDGFSF VPPQDDDNGA AGDQKIVADK
LAVTLDKNGS ASAVIAKLPA ISRAQELLTE MTYNDPNGEV QTISGVTPLW PSAVAVGLRA
GNWISVKKKL TLTAVTLDTD GKPQAGMAVE IRAIARKTNS HRKRMVGGFY AYENDQTTQD
LGKLCAGKSD AHGMFNCDTE LSEPGNVELI ASAKDARGNT SAAYSSVWVT GRGELWFDGE
NQDRIDILPE KKTYQAGETA RFQVRMPFRH ATALVAVERE GVIDTQVVQL SGQDPNISVP
VKAAYGPNVY VSVLAVRGRM RDVPWYSFFL WGWKEPVNWW HEFREYQAPG TMVDLSKPAW
KYGIAEIGVG EAAHKLQVAV STDKSSYPVR GVAKVQVQVK LPDGKPAAGA EFALAAVDEA
LLELQPNGSW DLLKAMLQRR SYGVETSTAQ MQVVGKRHYG KKATPAGGGG GRAPTRELFD
TLLLWKPSVK LDGDGRAQLE VPLNDALTSF RIVAIADSGA DLFGTGSTSI RATQDVQLIS
GLPPLVREGD SFNAMVTLRN TTNRDMKIKV VARAEGSALS LPERELALGA GQSGELAWPV
TVAQDLNQLN WEINAQEQGG AGARDAIKLS QRVLPAVPVT VQQATLFQLD KSASIDIVQP
AGSLPGRGGL AVGLKASLAG GSDALTRYFT QYPFSCLEQK TSKAIGLRDE AGWQRIAADL
PTYLDGDGLA YYFPPPDSSA RRGSDTLTAY LLAAANEAGY AIPTPSRDKM LDGLAGFVEG
RITRQFWSPR KDLDVRKLAA LEALSRYGRV QPAMLGSLQI NPNQWPTSGL LDWIAVLQRV
PAIAERQKKL DEADQILRAR LDFQGTRMGF SSEQDDYWWW LMSGADANAN RLILLQLNNP
AWRDDLPRLV AGAIARQQRG HWNTTTANVW GSLALDRFAR KFETEKPAGT TRVSVEPATQ
SFAWAAGSDG GKLQLPWPAT ASGGVARFAH DGAGKPWVTL QSLVAVPLTQ AFSSGYRITR
KIEAVEQKVG GSYSRGDVLR VSLEIDAQTD MTWVVVSDPL PGGATLLGSG LGRDSVIGQG
SQPRDDAGRG QLAYEERSFE AYRAYYESMP KGRTSISYTV RLNNVGEFNL PPTRVEAMYA
PEMFGELPNQ KMVVKAAP
//
