ID J3JU89_DENPD Unreviewed; 421 AA.
AC J3JU89;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=RNA-binding protein NOB1 {ECO:0000256|PIRNR:PIRNR037125};
GN Name=109538606 {ECO:0000313|EnsemblMetazoa:ENN76325};
GN ORFNames=D910_04375 {ECO:0000313|EMBL:ERL86972.1}, YQE_07288
GN {ECO:0000313|EMBL:ENN76325.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:AEE61764.1};
RN [1] {ECO:0000313|EMBL:AEE61764.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Midgut and adhering fatbody of emerged adults of both sexes 1
RC {ECO:0000313|EMBL:AEE61764.1};
RX PubMed=22516182; DOI=10.1016/j.ibmb.2012.03.010;
RA Keeling C.I., Henderson H., Li M., Yuen M., Clark E.L., Fraser J.D.,
RA Huber D.P., Liao N.Y., Roderick Docking T., Birol I., Chan S.K.,
RA Taylor G.A., Palmquist D., Jones S.J., Bohlmann J.;
RT "Transcriptome and full-length cDNA resources for the mountain pine beetle,
RT Dendroctonus ponderosae Hopkins, a major insect pest of pine forests.";
RL Insect Biochem. Mol. Biol. 42:525-536(2012).
RN [2] {ECO:0000313|Proteomes:UP000019118, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:ENN76325}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
CC -!- FUNCTION: May play a role in mRNA degradation.
CC {ECO:0000256|PIRNR:PIRNR037125}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR037125}.
CC -!- SIMILARITY: Belongs to the NOB1 family. {ECO:0000256|ARBA:ARBA00005858,
CC ECO:0000256|PIRNR:PIRNR037125}.
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DR EMBL; APGK01040876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BT126802; AEE61764.1; -; mRNA.
DR EMBL; KB740984; ENN76325.1; -; Genomic_DNA.
DR EMBL; KB631899; ERL86972.1; -; Genomic_DNA.
DR RefSeq; XP_019761478.1; XM_019905919.1.
DR AlphaFoldDB; J3JU89; -.
DR STRING; 77166.J3JU89; -.
DR EnsemblMetazoa; ENN76325; ENN76325; YQE_07288.
DR GeneID; 109538606; -.
DR KEGG; dpa:109538606; -.
DR HOGENOM; CLU_024666_0_0_1; -.
DR OMA; GYELECE; -.
DR OrthoDB; 5473723at2759; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; IEA:InterPro.
DR CDD; cd09876; PIN_Nob1-like; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 6.20.210.10; Nin one binding (NOB1), Zn-ribbon-like; 1.
DR InterPro; IPR039907; NOB1.
DR InterPro; IPR017117; Nob1_euk.
DR InterPro; IPR036283; NOB1_Zf-like_sf.
DR InterPro; IPR014881; NOB1_Zn-bd.
DR InterPro; IPR033411; Ribonuclease_PIN.
DR PANTHER; PTHR12814; RNA-BINDING PROTEIN NOB1; 1.
DR PANTHER; PTHR12814:SF2; RNA-BINDING PROTEIN NOB1; 1.
DR Pfam; PF08772; NOB1_Zn_bind; 1.
DR Pfam; PF17146; PIN_6; 1.
DR PIRSF; PIRSF037125; D-site_20S_pre-rRNA_nuclease; 1.
DR SUPFAM; SSF144206; NOB1 zinc finger-like; 1.
PE 2: Evidence at transcript level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR037125}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR037125};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRNR:PIRNR037125}.
FT DOMAIN 12..98
FT /note="Ribonuclease PIN"
FT /evidence="ECO:0000259|Pfam:PF17146"
FT DOMAIN 273..344
FT /note="Nin one binding (NOB1) Zn-ribbon-like"
FT /evidence="ECO:0000259|Pfam:PF08772"
FT REGION 196..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 283
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR037125-1"
FT BINDING 286
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR037125-1"
FT BINDING 298
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR037125-1"
FT BINDING 301
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR037125-1"
SQ SEQUENCE 421 AA; 47934 MW; 6C48DF2E5BBDE33F CRC64;
MSSTGSKQVE VLVVDTTAFI QNAPLQQIAD KMVTCQEVVD EIRNKRQLRR LVVLPYDLEI
KHVFPENVQL ITEFSKKTGD YPSLSLTDIK VMALTYQLEK EKVGTAHLRT EPVQDRPIVN
TEKPADEIHP DITGFFLPGS QNPHNAETDE SAQEIDPIQA EKDMAIELQE FSAKFEKLNC
NDDDLKVEED ILVPVKDESC SEEEQSSSES QEDEDEEVGW ITPANIAIAK KQVNSQLMEE
KHVQVACMTT DFAMQNVLRQ INLNVSALDG RIIKQLRTYI FRCYSCFKTT SIMTKKFCPK
CGNSTLKRVG ASLDENGKMQ IHINSRRPLT GRGKKFSLPR IQGGKHPNNP ILVEDQPMPD
NRPTRLARMK CNPLDDDYTA GYSPFIMRDV YSKSAQLGIR PGVEFKQWMK RNPNESRRKR
K
//
