ID J3JX45_DENPD Unreviewed; 143 AA.
AC J3JX45;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] {ECO:0000256|ARBA:ARBA00018911};
DE AltName: Full=Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase {ECO:0000256|ARBA:ARBA00032644};
GN Name=109544767 {ECO:0000313|EnsemblMetazoa:ENN70778};
GN Synonyms=109538612 {ECO:0000313|EnsemblMetazoa:ENN82966};
GN ORFNames=D910_03639 {ECO:0000313|EMBL:ERL86228.1}, YQE_00666
GN {ECO:0000313|EMBL:ENN82966.1}, YQE_01247
GN {ECO:0000313|EMBL:ENN82381.1}, YQE_12443
GN {ECO:0000313|EMBL:ENN70778.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:AEE62775.1};
RN [1] {ECO:0000313|EMBL:AEE62775.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Heads {ECO:0000313|EMBL:AEE62775.1};
RX PubMed=22516182; DOI=10.1016/j.ibmb.2012.03.010;
RA Keeling C.I., Henderson H., Li M., Yuen M., Clark E.L., Fraser J.D.,
RA Huber D.P., Liao N.Y., Roderick Docking T., Birol I., Chan S.K.,
RA Taylor G.A., Palmquist D., Jones S.J., Bohlmann J.;
RT "Transcriptome and full-length cDNA resources for the mountain pine beetle,
RT Dendroctonus ponderosae Hopkins, a major insect pest of pine forests.";
RL Insect Biochem. Mol. Biol. 42:525-536(2012).
RN [2] {ECO:0000313|Proteomes:UP000019118, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:ENN70778}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Nudix hydrolase family.
CC {ECO:0000256|ARBA:ARBA00005582}.
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DR EMBL; APGK01008348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; APGK01013783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; APGK01057784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BT127813; AEE62775.1; -; mRNA.
DR EMBL; KB741282; ENN70778.1; -; Genomic_DNA.
DR EMBL; KB739113; ENN82381.1; -; Genomic_DNA.
DR EMBL; KB737669; ENN82966.1; -; Genomic_DNA.
DR EMBL; KB631802; ERL86228.1; -; Genomic_DNA.
DR RefSeq; XP_019761488.1; XM_019905929.1.
DR RefSeq; XP_019761497.1; XM_019905938.1.
DR RefSeq; XP_019770660.1; XM_019915101.1.
DR RefSeq; XP_019771056.1; XM_019915497.1.
DR AlphaFoldDB; J3JX45; -.
DR STRING; 77166.J3JX45; -.
DR EnsemblMetazoa; ENN70778; ENN70778; YQE_12443.
DR EnsemblMetazoa; ENN82381; ENN82381; YQE_01247.
DR EnsemblMetazoa; ENN82966; ENN82966; YQE_00666.
DR GeneID; 109538612; -.
DR KEGG; dpa:109538612; -.
DR HOGENOM; CLU_037162_14_5_1; -.
DR OMA; WRDYEQA; -.
DR OrthoDB; 196203at2759; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0008796; F:bis(5'-nucleosyl)-tetraphosphatase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR CDD; cd03428; Ap4A_hydrolase_human_like; 1.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR020084; NUDIX_hydrolase_CS.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR InterPro; IPR003565; Tetra_PHTase.
DR PANTHER; PTHR21340:SF0; BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL]; 1.
DR PANTHER; PTHR21340; DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT; 1.
DR Pfam; PF00293; NUDIX; 1.
DR PRINTS; PR01405; TETRPHPHTASE.
DR SUPFAM; SSF55811; Nudix; 1.
DR PROSITE; PS51462; NUDIX; 1.
DR PROSITE; PS00893; NUDIX_BOX; 1.
PE 2: Evidence at transcript level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742}.
FT DOMAIN 2..134
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS51462"
SQ SEQUENCE 143 AA; 16605 MW; 144A74990663D5C0 CRC64;
MAPKVAAGFV IFRYASSKIE YLLLQTSYGI HHWTPPKGHV DPGETDLMTA YRETQEESGL
KKADIKVFEE TKTTLNYKVK GKPKVVHYWL AELINPDAKV KLSNEHQDFK WLPLKEACEI
SGYQDMEDVL NKFDEFLRKE RNL
//
