ID J3K0N0_COCIM Unreviewed; 999 AA.
AC J3K0N0;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Hydantoinase {ECO:0000313|EMBL:EAS27414.3};
GN ORFNames=CIMG_10019 {ECO:0000313|EMBL:EAS27414.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS27414.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; GG704915; EAS27414.3; -; Genomic_DNA.
DR RefSeq; XP_001238997.1; XM_001238996.1.
DR AlphaFoldDB; J3K0N0; -.
DR GeneID; 4557990; -.
DR KEGG; cim:CIMG_10019; -.
DR VEuPathDB; FungiDB:CIMG_10019; -.
DR InParanoid; J3K0N0; -.
DR OMA; RVNYSMP; -.
DR OrthoDB; 307246at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 2.40.390.10; CV3147-like; 1.
DR Gene3D; 3.40.1610.10; CV3147-like domain; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR048350; DUF917_C.
DR InterPro; IPR024071; DUF917_C_sf.
DR InterPro; IPR010318; DUF917_N.
DR InterPro; IPR027479; DUF917_N_sf.
DR InterPro; IPR008040; Hydant_A_N.
DR InterPro; IPR002821; Hydantoinase_A.
DR InterPro; IPR045079; Oxoprolinase_fam.
DR PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR PANTHER; PTHR11365:SF10; HYDANTOINASE; 1.
DR Pfam; PF06032; DUF917; 1.
DR Pfam; PF20906; DUF917_C; 1.
DR Pfam; PF05378; Hydant_A_N; 1.
DR Pfam; PF01968; Hydantoinase_A; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF160991; CV3147-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001261}.
FT DOMAIN 9..190
FT /note="Hydantoinase/oxoprolinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF05378"
FT DOMAIN 210..389
FT /note="Hydantoinase A/oxoprolinase"
FT /evidence="ECO:0000259|Pfam:PF01968"
FT DOMAIN 606..765
FT /note="DUF917"
FT /evidence="ECO:0000259|Pfam:PF06032"
FT DOMAIN 768..983
FT /note="DUF917"
FT /evidence="ECO:0000259|Pfam:PF20906"
SQ SEQUENCE 999 AA; 107873 MW; AD3000795AE1035A CRC64;
MAAAIKPYRI GVDVGGTNTD AVILDTRETK SANRGVVAWH KTPTTSPNVT DGIEAAVRSV
LDQSKAPRDQ VACLTIGTTH FINAIVEHDA RRLSKVAIIR LSRTFTREVP PFSDFPPVLK
SIMNGYYCYV DGGLHIDGSQ EAPINEDQIV RECAIIKEKG LDAVVISGVF SPIDDHFYQE
DHVRRIVRRE LPDVDIVCSS EVSQIGYLER ENASILNASI LKFARRTIRG FKNAMKRLDL
NCTLYLTQND GTLIDAPSAA RLPIRTFSSG PTNSMRGAAY LGLSGQSDGT EEKTATIVVD
IGGTTSDVGV LLPSGFPRQA SAYVTVAGVQ INFGMPHLES IGLGGGSIVR SENGKVTVGP
DSVGHFLSTR AKVFGGDVLT ATDIAVAAGE KIGDPNLVQD VDQNTVADAR ARMKTMLENV
VDLMKTSPAP LPVLLVGGGS AIAPTELDGV SKVICPPFHS VANAVGAAMS KVGGTVDMIQ
SSEERTVKEI VEQAKETAIE RAVASGALRE TVYLAEVDAL PLQYVANQVR VIARAVGELS
PDGVPPSDSL LDDDDEDDEQ IYKEAAKRDA HLDEPNAAAI DIEKYRPKVV KNPKTGVPEW
IVSELDVQWI ADGCYVLGCA GGGSPFGEYI RIRDQIRQGH TIRIIDASSL PKDALIYWGG
HMGSPAVSVE RLAHEETEHA FLELMEYLKH DSIDAVMGLE IGGANGLQPL ALGSTKNHDC
PVIDADWMGR AYPTYWQTTM CVYEEKQLVP CAIASGDGRS IIMTKTTDDE IVDRALRASC
SEMGSRVGMA AKPTTTDRVH KYSVINTISL AWRIGRCIAR AHANNTLSTV AEQMIDEIGG
PETAKVLFRG KIIAVERRLF KGHSYGEITI QQTQQSEEEK SGSDNVPAVA VGGTLKIPFK
NENIYAKHIS ETGEEKYIAM VPDLISVLDT QSGKALGVPE FRYGLMVTVL GIACSPRWSD
TPRGLEYGGP GAFGYKNIEY KPLGTYVEPK SVVFEFAED
//
