ID J3K597_COCIM Unreviewed; 1026 AA.
AC J3K597;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Cep57 centrosome microtubule-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CIMG_08326 {ECO:0000313|EMBL:EAS29580.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS29580.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; GG704913; EAS29580.3; -; Genomic_DNA.
DR RefSeq; XP_001241163.2; XM_001241162.2.
DR AlphaFoldDB; J3K597; -.
DR GeneID; 4560324; -.
DR KEGG; cim:CIMG_08326; -.
DR VEuPathDB; FungiDB:CIMG_08326; -.
DR InParanoid; J3K597; -.
DR OMA; MKSDQIY; -.
DR OrthoDB; 2729811at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR InterPro; IPR024957; Cep57_MT-bd_dom.
DR InterPro; IPR025925; PPC89_CLD.
DR PANTHER; PTHR19336:SF9; SPINDLE POLE BODY PROTEIN PPC89; 1.
DR PANTHER; PTHR19336; UNCHARACTERIZED DUF1167; 1.
DR Pfam; PF14197; Cep57_CLD_2; 1.
DR Pfam; PF06657; Cep57_MT_bd; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261}.
FT DOMAIN 422..488
FT /note="PPC89 centrosome localisation"
FT /evidence="ECO:0000259|Pfam:PF14197"
FT DOMAIN 862..938
FT /note="Cep57 centrosome microtubule-binding"
FT /evidence="ECO:0000259|Pfam:PF06657"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 830..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 980..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 349..390
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 153..174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..526
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..649
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..776
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..1000
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1026 AA; 114961 MW; 67412CFD610AD395 CRC64;
MSPNDHTSTS DVLARSQPSR DSTLSDFDPD NDVLISTQQL ANENALKEAE DLDYAIDTSA
LHRALPHFTD ASSSDESEAL SIEIGRGGRN IPRTDHTHSS VLSFEDSKLA TSPGARREDL
PEPQCSRPAL RSISNRTVMR NQDNLRKDAQ IRHASHVSQK ENLDPKELKI RSRRQANSSR
RPSRTQRRTL SDMHAKVLES YEGSYLSDER PPTLDGQSKN TRFGSKKGQK HVESIAHAVN
NAAGKPYPGI GQNVADFTEE NNTDMTGTND ALHETANHES FILPDMPDMS ELVSGIYHEG
MPAGTRQGRS RTTRFASPPA VTISAASQEH VAFDGVPIPE DEKAIFASLK LLQNKVSSLE
KENLLVENRL EELQQENQVL RAERSSRKKR EEGKLHMYRR TEDESGRGAA TLAVERNNDL
GLETANMALQ NRLDIANHKI AGHDGNMRRV MKERDTVMNK LGVAYLSCQE LRSQNESLRR
DNEELRSQLL LLTSMPNVDE SNPDALSKAK AHKEETTSRS GSRRRRNSEL LDLEFLDEGD
LGVEEGPEDP CNGHRKHHRC CHTHDQTLES TQDDALRSKQ RQNHYEDLFS LDLSKRCRSK
SRERRRGSRS QTGKEKKEPN TSKQRVKRAV MENDSDLSDA EITVESKYPR TDGRNTQDLT
FLSFIDRHEI ALLRKTLEEE RIARKQRRAK ETTQVPLKGA ARAHFDPLQL DNLTTGSNVQ
ESRIEPQAGR EPATNAKLKI SEPDTAQARD EMAAPETAQS TRSMPGRRRS QSKAGDMTSA
IILPDITLHG VTSKYEAIKV SAAAQRVLDE VASHEKENCF VCHESQKHNP AQESVNLPPI
KVPRPIPVSQ RRPGPSACGN EPTLRPSQKP SIALASVLKA LEDELAHLKM QLTVFQTTYA
KHDPSLNKRQ RKAMCPKIAI LMTEIEKKSD QIYSLYDVLE GQKKHGEEMT EEEVEVTLHS
LGIAAPVSRQ PNLTERLGQD FQEGKHNTAH EAKLSDSDDE ELPWEGFDDT IESTSKAFSA
KKPSGY
//
