ID J3K8L2_COCIM Unreviewed; 734 AA.
AC J3K8L2;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN ORFNames=CIMG_06646 {ECO:0000313|EMBL:EAS31167.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS31167.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
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DR EMBL; GG704912; EAS31167.3; -; Genomic_DNA.
DR RefSeq; XP_001242750.2; XM_001242749.2.
DR AlphaFoldDB; J3K8L2; -.
DR STRING; 246410.J3K8L2; -.
DR GeneID; 4562008; -.
DR KEGG; cim:CIMG_06646; -.
DR VEuPathDB; FungiDB:CIMG_06646; -.
DR InParanoid; J3K8L2; -.
DR OMA; CWARQTI; -.
DR OrthoDB; 2712461at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR Gene3D; 6.20.120.20; -; 1.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11764:SF76; TERPENE CYCLASE_MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU362003};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 89..342
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 395..725
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 734 AA; 83740 MW; 91DE9B7CABBF333B CRC64;
MTGRNTRAAN ENGSVRSGQG GADDQTDYSR WRLLNDCGRQ TWHYLTAARE LEQWPQSIAD
KYHLGLPTGL PELPRATSPV EAAENGLSFL SHLQLPPGNW ACEYGGPMFL LPGLVVTWYV
TGTSVPPQFA TEIKRYLFAR QHPKDGGWGL HIEAHSSVFG TAMNYTALRL LGASAEDPRM
IKARGLLHKF GGAVYGPHWA KFWLSVLGVM EWECVNPLPP ELWLLPDWVP FAPWRWWVHM
RQVFLPMAYI YSRRFSHPLD GLTSQLRQEL YTEPYEAISF ASYRGTIAKE DNHSPKSWIL
NVIFWFVVNI WNVYLRWPAL VKKAEDRVWY LIQREDENTD YADLGPVNAS MNTICCYIHD
GPGSFPVHRH LDRLHDFLWM KSEGMLMNGT NGVQVWDTAF IIQAAVVTGF ANDTRWRPML
MKALEFLEAH QMLENIPEEE KCYRFRAKGA WPFSTKVQGY TVSDCTAEAL RAVLQLQNQL
GFTPLILQRR LKDAVDTLLE MQHDTGGFAD YEPTRASRHI EFLNAAEVFN GVIVGSDFTE
CTAAAITALS YFSRFYPDYR VDDIKRAQDK AVAYIRRAQE PDGSWYGSWG ICFTYAAMFA
LEALAMVGET YETSQRARRG CQFLLDKQMA DGGWGESYHS SVSKTYTHSK TSQVVQTAWA
SLALMEAGYP NREPLRRAMN VIMLKQQPNG EWLQEGIEGV FNQSCMISYP NYKLYWPVRA
LGLYAKKFGN EDIL
//
