ID J3K8N3_COCIM Unreviewed; 2516 AA.
AC J3K8N3;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 08-NOV-2023, entry version 56.
DE SubName: Full=Beige/BEACH domain-containing protein {ECO:0000313|EMBL:EAS31195.3};
GN ORFNames=CIMG_06674 {ECO:0000313|EMBL:EAS31195.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS31195.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; GG704912; EAS31195.3; -; Genomic_DNA.
DR RefSeq; XP_001242778.2; XM_001242777.2.
DR STRING; 246410.J3K8N3; -.
DR GeneID; 4560733; -.
DR KEGG; cim:CIMG_06674; -.
DR VEuPathDB; FungiDB:CIMG_06674; -.
DR InParanoid; J3K8N3; -.
DR OMA; EMSNFHY; -.
DR OrthoDB; 5478899at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46108; BLUE CHEESE; 1.
DR PANTHER; PTHR46108:SF4; BLUE CHEESE; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 2.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 1731..1862
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 1901..2196
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2328..2369
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1088..1111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1624..1702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1624..1668
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2516 AA; 283629 MW; CB4A58907DDD84A3 CRC64;
MSSVLLRPRR QSSPAATERL TSKLRPAIDA LAGSIRDSLC LDDALAATES IICLRHAFLD
DAQPLEARDA FRHLRGFQVL LDLLERLAHL YEPKAFDPQQ RRAVLALVKE VIGVLGETLK
DHHGNKRYFA RRVHGSGEPS FEQILSSLSG KLEENTDGDK DLEVEQFYGG LLAAGLGQQT
VSGLFTSLRK KFDNDIEVLP AAIKEAIEDA IGSSEVVENP EFFGPLLQLW LEQSLELSKY
PIQRLVVPAC LGRLAAQSSR NRLALHSTGM LTSLSGLITN SNRNREELAL YYELAVVLSS
EGFDNLDDAA ELYRKAHGSV EASRFLLATI KSSKEPPLVQ FDMSSHGYSS IELPTLGRPF
PPIASAGYTL TVWARFDTFD PKVHTTIFGA FDATQTCFLL AYLEKDTRNL ILQTSITGSR
PSVRFKSTVF SPGVWYHICI VHKRPRPISS SRALLFINGE LVEQLKADYP QVPASRSGQK
QARIQAFLGT PQDLALRVGK GLSASSWSLA SAVLFEEAFT DDIISVLCQL GPRYYGNFQD
CLGSFQTYRA SATLNLRNEN FHPGKEEHSD IVAVIRQKAS ILIPENSILL NISPTAVLDG
DASNIDESQL VKSLSRNPAR HLNHFLKAGG NSVAINRAVP AINRALTEPQ GVAILTGNPV
LSLPQSLDDA AWRIGGCAAV HLNMIEAATT PEHLRLAVEI LLESVQDSWR NSEAMEKENG
YGILGILLRE KLGITAAIPN APIKVASVCS NLQERNELSM ELLILILKFV GYDFNNPKKS
IIINPLAYRV LLVDLDIWRL GDLPLLEVYY SQFRTFCIES YYHRFNAKRL SRMRVIKRLL
DSLKDGIFTA DNIKLFIPAF SCLTTCCMMA EILRSIALFI TYSVHNPKPP SRLQNKKSTA
SITRQFRRAT APQFQGRMAV YISKEQIGVE LLRTFADIFC ASENTANIQK FARTVTNKWL
LYLISEDNAD VVIQATRILA RLLTVHGSSY TRKFDKSGGF VILRHCLKRW WSLPALWLFC
FAVLFGQDVK SIDMEQGFDR AAFTALLENS EKVKVACPEV FPVITGMLQS ALKSFILETR
AVERPEESDD DLWLGGSGRR EKSNSISEAT NGREGLHEDL LENVVHFLAN IHTKCSDFRD
FAATSNYVDE LLLVLFPVVV GSDAVNASME LNSRNSSLTF GSDSVVIQPL SNARPVLRTS
TVERCGGEEG GDSFRRGSSF ILVSSDKAKY NPSSARLRHV VEPKADVAST VPAHSVVQEL
LDLVVSVLMD QLLTRKEFSG LSIFLKMPPG FIEHQVYFES WLQRNILLQI ESNVLLNRKA
LLEPRVLNNL ARLLTQVADA IYEGWFIDGA TVTLDFAGPI LEYLQKSEVA SLKSIRLCSQ
TIGNIRSIVF RTVLLRLSET EDAAALSFLK RLTYWQTVLL GSEETQAEHL QLMCYLLYSK
IVTEEEDVRL QAAGLWRIIM VQKPTETLAM LSQTSSSLHK RLSTGFQKLV AMDNSSFLRW
IDDQRDDLDC FFFGTLSKVW ENFVRQENNK TDDTARNRLS KRKEKLKQWS QTDEANEEII
RRHDVTFGHW TSNISLSEKL KHQRYAQDQQ DDFTFLLSIF SRVYRNLRRE NGLLADRSET
KWRLDQTEGR SRMRQRIIPD DTVGKQDYQP KRRATESHPS KSDTRPRSNT DSDGVSITPS
EIAAEGLEEG SLVDDNGDGA GMDDSFEIIE EPKDGEEDYE DKNRKVMRSL HRGDQVQHVC
NISRIVGLEA CEGLLILGKD SIYIMDNYFQ RPDGEIVNVW QAPREERDPY VRMISGRESS
ERKYNNGEHE TRSWKWLDVV SVSKRRFLFR DVALEIFFTD GRSFLITLIS PPARNELHTR
LISRAPQTQA ASNSSQADDS WRFEALRSQE TKPQFFGSKL VNVFGQGGLH PATRKWLKGE
MSNFHYLMLV NTLAGRTFND LTQYPVFPWV LADYTSEELD LTNPKTFRDL SKPMGCQTPE
REAGFRSRYQ SFAEMGDHNA PPFHYGTHYS SAMIVCSYLI RLQPFVKSYL LLQGGTFDHA
DRLFYSVPKA WDSASTSNMT DVRELTPEFF YLPEFLLNSN KYDFGLRQNM TQAIDAVELP
PWAKGDPKIF IAKHREALES PYVSRNLHRW IDLIFGFKQK GEAALEAVNV FHHLSYQGAR
DLDSIDDPLE RLATIGIIHN FGQTPHQVFN KPHPQREEVH HKLNQLDIAA EGLTRLPFAL
LDTQERVASL SFSVKHDRLL CAAAFRLNIP PNYDKYMEWG FSDNSVRFYA SDTRRLVGHF
EHLHIGQLSC ALFADSQTLI TSGVDCVISV WSYTTTTKSV ELHPKASLFG HRTPVALLAV
ARSFSTILSS SKDGRLMLWD LNRLEFVREL PAGEPVDVSK KHARINDATG NIMVCRGSRV
SLYTLNGALL LEQVVCDQNE DCILSCAFYE GVSNEWLERE LIFTGHRRGL VNVWSKTIRN
GRFELDLIRQ LHHVDQVRGD GAVSSTGITY ILPLAQAVYT GDEAGSVYEW TCVQRR
//
