ID J3K9E2_COCIM Unreviewed; 258 AA.
AC J3K9E2;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=HpcH/HpaI aldolase/citrate lyase family protein {ECO:0000313|EMBL:EAS31511.3};
GN ORFNames=CIMG_06990 {ECO:0000313|EMBL:EAS31511.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS31511.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SIMILARITY: Belongs to the HpcH/HpaI aldolase family.
CC {ECO:0000256|ARBA:ARBA00005568}.
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DR EMBL; GG704912; EAS31511.3; -; Genomic_DNA.
DR RefSeq; XP_001243094.2; XM_001243093.2.
DR AlphaFoldDB; J3K9E2; -.
DR STRING; 246410.J3K9E2; -.
DR GeneID; 4560815; -.
DR KEGG; cim:CIMG_06990; -.
DR VEuPathDB; FungiDB:CIMG_06990; -.
DR InParanoid; J3K9E2; -.
DR OMA; WNRVDDY; -.
DR OrthoDB; 2785075at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.60; Phosphoenolpyruvate-binding domains; 1.
DR InterPro; IPR005000; Aldolase/citrate-lyase_domain.
DR InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR InterPro; IPR040442; Pyrv_Kinase-like_dom_sf.
DR PANTHER; PTHR30502; 2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE; 1.
DR PANTHER; PTHR30502:SF0; PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN; 1.
DR Pfam; PF03328; HpcH_HpaI; 1.
DR SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:EAS31511.3};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261}.
FT DOMAIN 27..242
FT /note="HpcH/HpaI aldolase/citrate lyase"
FT /evidence="ECO:0000259|Pfam:PF03328"
SQ SEQUENCE 258 AA; 27403 MW; B38C09A0FEA75AB8 CRC64;
MQAANRLRTV LQAGRGQAFG AWQMLPGTNV ARILARSGFD WICVDTEHGN IADAQMHEAV
AAIAALGVSP IVRIAANEGW MVKRALDSGA HGILVPLLDT ADDARKLVAS AKFPPMGKRG
FGSPFAMGPI GNVSATEYLL HANDTLLTIV QIETKEGLEN VEEIARVPGI DVLLVGPYDL
GNNIGRPVIN EFHPELEAAI ERIRKAAVDN GKKAGIFSPN GEMAKKFASQ GFHMISVTSD
VYALSTHLEG SLTTAKAG
//
