ID J3KA16_COCIM Unreviewed; 448 AA.
AC J3KA16;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=FAD-binding domain-containing protein {ECO:0000259|Pfam:PF01494};
GN ORFNames=CIMG_07299 {ECO:0000313|EMBL:EAS31820.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS31820.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SIMILARITY: Belongs to the paxM FAD-dependent monooxygenase family.
CC {ECO:0000256|ARBA:ARBA00007992}.
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DR EMBL; GG704912; EAS31820.3; -; Genomic_DNA.
DR RefSeq; XP_001243403.1; XM_001243402.1.
DR AlphaFoldDB; J3KA16; -.
DR STRING; 246410.J3KA16; -.
DR GeneID; 4562384; -.
DR KEGG; cim:CIMG_07299; -.
DR VEuPathDB; FungiDB:CIMG_07299; -.
DR InParanoid; J3KA16; -.
DR OMA; CAEGIHS; -.
DR OrthoDB; 1422702at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR002938; FAD-bd.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR PANTHER; PTHR13789; MONOOXYGENASE; 1.
DR PANTHER; PTHR13789:SF236; MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G12060)-RELATED; 1.
DR Pfam; PF01494; FAD_binding_3; 1.
DR PRINTS; PR00420; RNGMNOXGNASE.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261}.
FT DOMAIN 15..344
FT /note="FAD-binding"
FT /evidence="ECO:0000259|Pfam:PF01494"
SQ SEQUENCE 448 AA; 49085 MW; B1DBF69FE3E124A3 CRC64;
MAMHEDPVAS STGIKVIIVG FGIAGASAAI ECHRKGHNVV VYERLPELTK VGGDGISLGS
NGCSVLSKWD NGEFNETIKP LKFRTDNMNI FDYTGFDLGK HKFHGYNAGR GYTLNRGSLV
FSMYDYAQKL GIKVFMGSTV TEYWETEDEA GIVVNGEKVA ADCVICAEGI HSKGRAAITG
QEMQCKETGF VSTRGYLEGK AAIQGPSLTR IVSGMEDGNC MYGWMGPRMH ISMGIKIDGG
ELFWYACHEA ASVPPKNNSE AIDHILECMS DWTMRDELES VVRNVSEGRF ISQKLVVTTA
LKSWLSPRRR MIVIGDAAHA ALPTSGQGGT QAIEDAAVLA IALELAGKQD IPLALSVTEK
IRFKRAQLIQ QGGLAVLKFG MNRSDFELFR KDPNLARPPH PAWIFDHDCQ EYTYREFAAA
AEAVRSGKDY VPTNIPADGE YRIAYDSK
//
