ID J3KBB1_COCIM Unreviewed; 555 AA.
AC J3KBB1;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Protein arginine methyltransferase RmtB {ECO:0000313|EMBL:EAS32393.3};
GN ORFNames=CIMG_03417 {ECO:0000313|EMBL:EAS32393.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS32393.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; GG704916; EAS32393.3; -; Genomic_DNA.
DR RefSeq; XP_001243976.2; XM_001243975.2.
DR AlphaFoldDB; J3KBB1; -.
DR STRING; 246410.J3KBB1; -.
DR GeneID; 4564562; -.
DR KEGG; cim:CIMG_03417; -.
DR VEuPathDB; FungiDB:CIMG_03417; -.
DR InParanoid; J3KBB1; -.
DR OMA; DGWAVWF; -.
DR OrthoDB; 197898at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016274; F:protein-arginine N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR049482; ANM3-like_C2H2_Zf.
DR InterPro; IPR025799; Arg_MeTrfase.
DR InterPro; IPR041698; Methyltransf_25.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR PANTHER; PTHR11006; PROTEIN ARGININE N-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11006:SF116; PROTEIN METHYLTRANSFERASE; 1.
DR Pfam; PF21137; ANM3_C2H2_Zf; 1.
DR Pfam; PF13649; Methyltransf_25; 1.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51678; SAM_MT_PRMT; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01015}; Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01015};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01015}.
FT DOMAIN 81..125
FT /note="Protein arginine N-methyltransferase 3-like C2H2
FT zinc finger"
FT /evidence="ECO:0000259|Pfam:PF21137"
FT DOMAIN 258..355
FT /note="Methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13649"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 150..177
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 555 AA; 62753 MW; 3A16AF4F45A64FE0 CRC64;
MTDSELPARP REAVDDVEDS SSESSPSECL DLTKDDGWED VEPDEEVNPV VDLFSDKVFP
DTRSMLQHCK ENFNFDLVKV QKQLGLDFLG TIKLVNYIRS EVQSGNTKPD VSSSAPFEDD
KYLKPVLEDD ALLYTLEDIS DGDEDLGQQA ANPTSRIRDL EEELSRLREE FVEYKNMVQR
SLSKQLGSEV ENGSQIPPNQ NQNEHVTETR RYKDAEAGYF TSYAYNTIHE SMLKDTVRTD
SYRDFIYDNK SIFKDKVVLD VGCGSGILSM FCAKAGAKMV IAVDNSDIID KARQIVYENG
FGDVIKCIRG KIEEVVLPVK QVDVIVSEWM GYCLLFEAML DSVLFARDRY LAPGGLMVPS
HATLRIAPIA DSDFIDEHIS FWNSVYGFKM SGMLENVYDE VLIQTISPSA MVADSALFLS
LPLHTITVEE LTFVKEFKVA ITKDADTLDG WLVWFDMFFM PSCESKLADN ATPGEMKKSG
YVAFTTGPDG KETHWQQGVF LINRGKHQER PLKKGQVIKG KIGYKKKEEQ SRLLDIDIEW
AVDEEPPVHQ EWALQ
//
