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Database: UniProt
Entry: J3KDM0_COCIM
LinkDB: J3KDM0_COCIM
Original site: J3KDM0_COCIM 
ID   J3KDM0_COCIM            Unreviewed;       520 AA.
AC   J3KDM0;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 2.
DT   05-JUN-2019, entry version 35.
DE   SubName: Full=Phenylalanine-tRNA ligase, alpha subunit {ECO:0000313|EMBL:EAS33476.3};
GN   ORFNames=CIMG_04500 {ECO:0000313|EMBL:EAS33476.3};
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Coccidioides.
OX   NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS33476.3, ECO:0000313|Proteomes:UP000001261};
RN   [1] {ECO:0000313|Proteomes:UP000001261}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J.,
RA   Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E.,
RA   Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M.,
RA   Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N., Orbach M.J.,
RA   Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens
RT   Coccidioides and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2] {ECO:0000313|Proteomes:UP000001261}
RP   GENOME REANNOTATION.
RC   STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
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DR   EMBL; GG704914; EAS33476.3; -; Genomic_DNA.
DR   RefSeq; XP_001245059.1; XM_001245058.2.
DR   EnsemblFungi; EAS33476; EAS33476; CIMG_04500.
DR   GeneID; 4565139; -.
DR   KEGG; cim:CIMG_04500; -.
DR   EuPathDB; FungiDB:CIMG_04500; -.
DR   eggNOG; ENOG410IZE8; Eukaryota.
DR   eggNOG; ENOG410Y1DR; LUCA.
DR   InParanoid; J3KDM0; -.
DR   KO; K01889; -.
DR   OMA; QIEGWVM; -.
DR   OrthoDB; 733355at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004826; F:phenylalanine-tRNA ligase activity; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR   GO; GO:0006432; P:phenylalanyl-tRNA aminoacylation; IEA:InterPro.
DR   InterPro; IPR006195; aa-tRNA-synth_II.
DR   InterPro; IPR004529; Phe-tRNA-synth_IIc_asu.
DR   InterPro; IPR002319; Phenylalanyl-tRNA_Synthase.
DR   InterPro; IPR040725; PheRS_DBD3.
DR   Pfam; PF18553; PheRS_DBD3; 1.
DR   Pfam; PF01409; tRNA-synt_2d; 1.
DR   TIGRFAMs; TIGR00468; pheS; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001261};
KW   Ligase {ECO:0000313|EMBL:EAS33476.3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001261}.
FT   DOMAIN      223    513       AA_TRNA_LIGASE_II. {ECO:0000259|PROSITE:
FT                                PS50862}.
FT   REGION      279    306       Disordered. {ECO:0000256|MobiDB-lite:
FT                                J3KDM0}.
FT   COMPBIAS    279    295       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                J3KDM0}.
SQ   SEQUENCE   520 AA;  58753 MW;  F6A803F92E7C23D3 CRC64;
     MASDLTHQVL EALASTDKPI LSSDAFPSAP PTSVKSALDR LGSREMVQYE TLEREEAILS
     PEAEGIVANG SHEAKVFEAV RAALDGLKIA ELPNVVGKDA AKVGAGNAFK KGWIKKDKDT
     LRAVADSIED TAREQLHTIQ KTKTFPDAKV LADLRKRKLI TMQKVINYRI SKGPKYAREF
     VKEQTDLTVE MLADGSWKTA KLKPYNFNAK GAVTPSGAFH PLNKVRHEFR QIFFEMGFEE
     MPTNRFVETG FWNFDALFVP QQHPARDLQD TFYISDPAVA DKPRDDPKDH PHVSRDSNPA
     SYTKSDSVKP LDYERYWNDI HAVHETGKYG SIGYRYPWCA DESLRLVLRT HTTAVSAYML
     HKLAQNPRPA RYFSIDRVFR NEAVDATHLA EFHQIEGVIA DFGLSLGGLI GFMEVFFAKM
     GIHGLRFKPA YNPYTEPSLE IFGYHPTLKR WVEIGNSGMF RPEMLEPMGL PKDMRVYGWG
     LSLERPTMIK YGVSNIRELL GHKTDLNFIE SNPAVRLEKD
//
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