ID J3KHW1_COCIM Unreviewed; 436 AA.
AC J3KHW1;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Transcription factor TFIIE complex alpha subunit {ECO:0000313|EMBL:EAS35495.3};
GN ORFNames=CIMG_00849 {ECO:0000313|EMBL:EAS35495.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS35495.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; GG704911; EAS35495.3; -; Genomic_DNA.
DR RefSeq; XP_001247078.1; XM_001247077.2.
DR AlphaFoldDB; J3KHW1; -.
DR STRING; 246410.J3KHW1; -.
DR GeneID; 4567804; -.
DR KEGG; cim:CIMG_00849; -.
DR VEuPathDB; FungiDB:CIMG_00849; -.
DR InParanoid; J3KHW1; -.
DR OMA; DAIKWKV; -.
DR OrthoDB; 7984at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR InterPro; IPR039997; TFE.
DR InterPro; IPR017919; TFIIE/TFIIEa_HTH.
DR InterPro; IPR002853; TFIIE_asu.
DR InterPro; IPR024550; TFIIEa/SarR/Rpc3_HTH_dom.
DR PANTHER; PTHR13097:SF7; GENERAL TRANSCRIPTION FACTOR IIE, POLYPEPTIDE 1, ALPHA; 1.
DR PANTHER; PTHR13097; TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT; 1.
DR Pfam; PF02002; TFIIE_alpha; 1.
DR SMART; SM00531; TFIIE; 1.
DR PROSITE; PS51344; HTH_TFE_IIE; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 4..95
FT /note="HTH TFE/IIEalpha-type"
FT /evidence="ECO:0000259|PROSITE:PS51344"
FT REGION 292..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..357
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 436 AA; 48714 MW; DEE64D48546F433F CRC64;
MDLARSLIRI VARAFYETRH ILVIDALFIH SVLHAEDLAL LLGMQQKDLR KLCGRLREDR
LIAVHSRPEL REGQTRPVNR EYYYIPLHPV IDAIKYRVSR LTSTIKTQYT PSAERKEYIC
LRCQAEWTQL EVLSHVGLDG FECQRCGYLL SRADEVEGGG AADRTGHEKN SKLMAQLDPM
LKLLKQIDSV EVPPNDFDTA WDHKVDVIRN QYTNPSRPGV VVSKQSAVRG VSKTDASTLE
VSLTSTAEKS AEEQAREAAR KAALEKQNAL PIWHTQSTVS TVVRLPQVKT EPNGVSIKPE
VDIKPEVKEE QKPDIDSLDD SVAAYYAEMA REKEREAQED VSEEESDEEE DEFEDVEITP
SAVGTPANQA DATKAPSVNG SLKRELESDS GSSAPQTNAP TPITPGDEGP AAKKIKLEPE
VKKEESDEEE DEFEDV
//
