ID J3KJ72_COCIM Unreviewed; 1334 AA.
AC J3KJ72;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=ABC multidrug transporter {ECO:0000313|EMBL:EAS36076.3};
GN ORFNames=CIMG_01430 {ECO:0000313|EMBL:EAS36076.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS36076.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC Multidrug resistance exporter (TC 3.A.1.201) subfamily.
CC {ECO:0000256|ARBA:ARBA00007577}.
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DR EMBL; GG704911; EAS36076.3; -; Genomic_DNA.
DR RefSeq; XP_001247659.2; XM_001247658.2.
DR GeneID; 4567858; -.
DR KEGG; cim:CIMG_01430; -.
DR VEuPathDB; FungiDB:CIMG_01430; -.
DR InParanoid; J3KJ72; -.
DR OMA; DLQWHES; -.
DR OrthoDB; 1067095at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18577; ABC_6TM_Pgp_ABCB1_D1_like; 1.
DR CDD; cd18578; ABC_6TM_Pgp_ABCB1_D2_like; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; ATP-BINDING CASSETTE SUB-FAMILY B; 1.
DR PANTHER; PTHR24221:SF450; ATRH; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 37..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 742..768
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 788..815
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 866..887
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 893..911
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 972..994
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1006..1023
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..342
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 378..655
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 746..1034
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1084..1323
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1334 AA; 144477 MW; 2808DA60ED41E3A9 CRC64;
MTATNGESSD NSSKAPKSRT RTFTSYLRLF VYADPTFYDI LLLLGGVIAA IASGVSFPLL
AVLFGQVVDD LNSATCNAGF TSPSSYQSAV NEQVLKVVYI GIAYLILAYI SIVCWSLTGE
RLAQRIRQKY FKALLNQDVA FFDDLPAGAV SSRLNGDIAT IQNGTSEKVG LVLNSISFFV
TGYVVAFTKD AQLGGALVSL LPAFMLMSLV GSYFVQKYTG RITENVASST SVALEALSNI
MVVHALTANT RLESKFSNSL GRAKIAGIKK AIAAAIQAGL LFFIAYSANA LAYWLGSKKI
ADSVASGGTG ATVGSTYTVI VILVDASLIL STMAPFFQFF DSASVAFQQL EKDIDRKPKI
NGANENINQG IPNVVGHIQL QNVSFTYGSR PDKPVLQNVS FNCPEGKQTA IVGLSGSGKS
TVASLMMRFY DPDDGCIMID GHDIKDIGVQ FLRSYVSLVQ QEPCLLERSI FENIALGLIN
SPAHSHLRQT LQGAKLSEVA AAIREGQDLD RAAESHGPEV LEIVQLVKNA ATIADVSTFV
SRLKYGFGTL VGSSGSLVSG GQKQRISLAR ALIKDPKILI LDEATASLDS ASEQRVQAAL
EKAAVGRTLV TIAHRLSTIR NADNIIVMRN GQIVEQGTHT ELLAQEGSYA DLIRLQNLNV
HVEEDGQSSN SLVTDVTLED IPEKLSNEYT FTADEQLNKD YAIAEKTHPV EPATDEEDAG
LGAERPFSAT CSVLWGFFRP YILVLFLAFV AAIIVGGTYS ACAAVFGHTI GDLSPCKGES
RIRWAGNFYG LMFFVLAIIE FFANFASWSL FGLVAEKIVY KIRVLSFRAL LEQDLQWHES
NGRTPSRLLT LITKDGNALS GLTGSLVGNL VSVLVNFLTA VILTHIIAWK IALVFLAVVP
LMLGAGAMRV IQIARFEQHH AEAFAKSIAI TIEAVNSIKT VSSFSLEQEI FNTYRRSLQA
PTKAVTKHSA YASLWLAISY GLSNFLYALA YWWGARRVIS GDYSQAQFFI VLVALLVSAQ
LWGQMFTLAP DVSRAFTAIN RILNLLDLGS NSKLSKNRRN RRDIEAPSLT VEKNLDTNRG
GISVAFKQVT FSYPARPDVQ VLQGLDLSIQ PGQFAALVGP SGAGKSTIIS LVERMYTPSS
GVIQIDNKDI SKYEGVEFRN NIALVSQDNV LFDGSIRFNV ALGARPGHEP SDAEIEEACK
IANIHDTIIK LPEGYGTYCG PNGSQLSGGQ KQRLAIARAL VRKPRLLLLD ESTSALDAES
ERLLQNGLEK AAQGITVIAI AHRLNTIQKA NVIFLIEDGR CVDRGTHREL MDKSESYRVN
ALHQAVDGAK LSAK
//
