ID J3KJV4_COCIM Unreviewed; 507 AA.
AC J3KJV4;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Serine palmitoyltransferase 1 {ECO:0000313|EMBL:EAS36400.3};
GN ORFNames=CIMG_01754 {ECO:0000313|EMBL:EAS36400.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS36400.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
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DR EMBL; GG704911; EAS36400.3; -; Genomic_DNA.
DR RefSeq; XP_001247983.1; XM_001247982.2.
DR AlphaFoldDB; J3KJV4; -.
DR STRING; 246410.J3KJV4; -.
DR GeneID; 4566788; -.
DR KEGG; cim:CIMG_01754; -.
DR VEuPathDB; FungiDB:CIMG_01754; -.
DR InParanoid; J3KJV4; -.
DR OMA; LTKYGCG; -.
DR OrthoDB; 9643at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR13693; CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE; 1.
DR PANTHER; PTHR13693:SF2; SERINE PALMITOYLTRANSFERASE 1; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001261}.
FT DOMAIN 125..491
FT /note="Aminotransferase class I/classII"
FT /evidence="ECO:0000259|Pfam:PF00155"
SQ SEQUENCE 507 AA; 56325 MW; 0E526791D6C4C49A CRC64;
MMDLQEAQRV VLACLQALAN QFQRVPGSAI FIRYVKSSYQ NDPVRSAVEL FLFLFAVRYL
LAPKYSTKPN FVSLCEEEID DLVEDWSPDP LVPNPSPDDE AEVEKRVVLA GATGPKSKLT
NGRTVVNLAS YNHFNFVGSE FLKEKAVQTL RTYGVGPCGP PGFYGTQDVH MRTEADVASF
LGTPACIIYA QAFSTISSVI PAFSKRGDII VADKSVNFAI RKGIQISRSI VRWYEHNDME
DLERVLAKIT KEQAKKPLTR RFIITEALFE NRGDMVDLPK IVELRLKYKF RLILDETWSF
GVLGRTGRGI TEHQNVDPAQ VDMIVGSLAG PLIAGGGFCA GSEEIVHHQR ISATSYCFSA
ALPALLSTTA SESLTLLQES PELLTILRDN IKAMWSQLDR SDWVYCSSAP ENPIMFLPLK
PEVVSSRRLS VEDQQYIMQD IVDEALANGV LITRLKTIPD ESGPKLLGGQ VPPALKICLT
TGLSRKEVEK AGTIIRHSIT KVMRQKR
//
