ID J3KKA5_COCIM Unreviewed; 766 AA.
AC J3KKA5;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Exosome complex exonuclease Rrp6 {ECO:0000313|EMBL:EAS36589.3};
GN ORFNames=CIMG_01943 {ECO:0000313|EMBL:EAS36589.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS36589.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC {ECO:0000256|ARBA:ARBA00043957}.
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DR EMBL; GG704911; EAS36589.3; -; Genomic_DNA.
DR RefSeq; XP_001248172.1; XM_001248171.2.
DR AlphaFoldDB; J3KKA5; -.
DR STRING; 246410.J3KKA5; -.
DR GeneID; 4567203; -.
DR KEGG; cim:CIMG_01943; -.
DR VEuPathDB; FungiDB:CIMG_01943; -.
DR InParanoid; J3KKA5; -.
DR OMA; TMDIIWL; -.
DR OrthoDB; 2880475at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF08066; PMC2NT; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000313|EMBL:EAS36589.3};
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Hydrolase {ECO:0000313|EMBL:EAS36589.3};
KW Nuclease {ECO:0000313|EMBL:EAS36589.3};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 450..530
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 627..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 766 AA; 84393 MW; DF539E37F7EE55DD CRC64;
MDLATEFSPF QEKLTAALVQ ATKTTSQLLA QDIAFQRSVN PSLSNSLDEQ SARFLGLTNS
ILRFATSGSD LNAPSLEDED GVDENWRGVV DVIDELLEKA DACLDEFTGI IKKLGPSQDE
RGQELNKRAS RAQFPGAHNF ASSKIPKPQL SFKTRPNNHA SSPFRPILRQ KPHALIPLPP
VAEQTSTNGD VEQSEHPYAH EIRDCHYPAS TYSSSTPQLY KPFESTTATF VNTIEGVKVM
LEELKSAKEI AVDLEHHDAH SYHGLVCLMQ ISTREKDWIV DTLLPWREEL QILNEVFADP
RILKVLHGSS MDVIWLQRDL GLYLVGLFDT YHASVALNYP KKSLKFLLDK FVNLEAEKQY
QTADWRLRPL LPGMFDYARS DTHYLLYIYD NLRNELIEKS TPDTNLIDYV QDKSKEEALQ
RYERPVYDAE TGQGSGGWYD VLSRSPSLLK REQLAVFKAV HRWRDQTART DDEGVQSVLS
KRALFAIAHG MPSDQAALLK LAIPVSPSLR KRLSELLKVI KDAKASGVDG PELHEVLASG
PATLVSGVKA MEPSPAGAEK EASMASSAKA VRALVSQFWG TTLEQTESTN ASIYAPLAAA
DALALSLPLP SMPINISEEA HGIEDEAMET SATPPAPKFE KEDDRTSGLA PDQIFTVKQF
GAGPKRKAAP PDTELSPAPS PVSNSPHPDV AGPGSKKQKT SAAEDVVAPF DYAKAESVLQ
AGRAEDVRNL PRKPQFNPYA KALDAPQALR KSKKDMGGGK SFTFQK
//
