ID J3KNH0_HUMAN Unreviewed; 468 AA.
AC J3KNH0;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=KICSTOR subunit 2 {ECO:0000313|Ensembl:ENSP00000311486.8};
GN Name=KICS2 {ECO:0000313|Ensembl:ENSP00000311486.8};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000311486.8, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000311486.8, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RG Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A., null.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000311486.8}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- INTERACTION:
CC J3KNH0; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-17269253, EBI-10271199;
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DR EMBL; AC012158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF459550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; J3KNH0; -.
DR SMR; J3KNH0; -.
DR IntAct; J3KNH0; 1.
DR MassIVE; J3KNH0; -.
DR PeptideAtlas; J3KNH0; -.
DR Antibodypedia; 53140; 11 antibodies from 7 providers.
DR Ensembl; ENST00000311915.12; ENSP00000311486.8; ENSG00000174206.13.
DR UCSC; uc058qjb.1; human.
DR HGNC; HGNC:26517; KICS2.
DR VEuPathDB; HostDB:ENSG00000174206; -.
DR GeneTree; ENSGT00390000009583; -.
DR OrthoDB; 3062033at2759; -.
DR ChiTaRS; C12orf66; human.
DR Proteomes; UP000005640; Chromosome 12.
DR Bgee; ENSG00000174206; Expressed in secondary oocyte and 161 other cell types or tissues.
DR ExpressionAtlas; J3KNH0; baseline and differential.
DR GO; GO:0045171; C:intercellular bridge; IDA:HPA.
DR GO; GO:0005764; C:lysosome; IDA:HPA.
DR Gene3D; 1.10.3450.30; -; 1.
DR InterPro; IPR038060; C12orf66-like_central_sf.
DR InterPro; IPR018544; KICS_2.
DR PANTHER; PTHR31581; KICSTOR COMPLEX PROTEIN C12ORF66; 1.
DR PANTHER; PTHR31581:SF1; KICSTOR SUBUNIT 2; 1.
DR Pfam; PF09404; C12orf66_like; 1.
DR SUPFAM; SSF160651; FLJ32549 C-terminal domain-like; 1.
DR SUPFAM; SSF158548; FLJ32549 domain-like; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:J3KNH0,
KW ECO:0007829|PeptideAtlas:J3KNH0};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
SQ SEQUENCE 468 AA; 53184 MW; EB19CC34032CD6F5 CRC64;
MGESIPLAAP VPVEQAVLET FFSHLGIFSY DKAKDNVEKE REANKSAGGS WLSLLAALAH
LAAAEKVYHS LTYLGQKLGG QSFFSRKDSI RTIYTSLHNE LKKVVTGRGA LGGTAPHVEE
LLSHLSEQLC FFVQARMEIA DFYEKMYTLS TQKFINAEEL VGLLDAIMKK YSSRFHHPIL
SPLESSFQLE VDVLCHLLKA QAQVSEWKFL PSLVNLHSAH TKLQTWGQIF EKQRETKKHL
FGGQSQKAVQ PPHLFLWLMK LKNMLLAKFS FYFHEALSRQ TTASEMKTLT AKANPDFFGK
ISSFIRKYDA ANVSLIFDNR GSESFQGHGY HHPHSYREAP KGVDQYPAVV SLPSDRPVMH
WPNVIMIMTD RTSDLNSLEK VVHFYDDKVQ STYFLTRPEP HFTIVIIFES KKSERDSHFI
SFLNEVSLAL KNPKVFASLK PGAKGSCYQC NYFVAFCLNY SKLLLQRK
//
