ID J3KRE7_HUMAN Unreviewed; 1100 AA.
AC J3KRE7;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Lipoxygenase homology PLAT domains 1 {ECO:0000313|Ensembl:ENSP00000461964.1};
GN Name=LOXHD1 {ECO:0000313|Ensembl:ENSP00000461964.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000461964.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000461964.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A.,
RA Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q.,
RA Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [2] {ECO:0000313|Ensembl:ENSP00000461964.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; AC018931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC064800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC091139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KC877690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; J3KRE7; -.
DR SMR; J3KRE7; -.
DR MassIVE; J3KRE7; -.
DR Antibodypedia; 49424; 48 antibodies from 7 providers.
DR Ensembl; ENST00000582408.6; ENSP00000461964.1; ENSG00000167210.17.
DR UCSC; uc060ovl.1; human.
DR HGNC; HGNC:26521; LOXHD1.
DR VEuPathDB; HostDB:ENSG00000167210; -.
DR GeneTree; ENSGT00390000018830; -.
DR HOGENOM; CLU_009895_0_0_1; -.
DR ChiTaRS; LOXHD1; human.
DR Proteomes; UP000005640; Chromosome 18.
DR Bgee; ENSG00000167210; Expressed in left testis and 94 other cell types or tissues.
DR ExpressionAtlas; J3KRE7; baseline and differential.
DR CDD; cd01756; PLAT_repeat; 6.
DR Gene3D; 2.40.180.10; Catalase core domain; 4.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 5.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR PANTHER; PTHR45901:SF6; LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45901; PROTEIN CBG12474; 1.
DR Pfam; PF01477; PLAT; 7.
DR SMART; SM00308; LH2; 4.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 8.
DR PROSITE; PS50095; PLAT; 8.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|ProteomicsDB:J3KRE7};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 1..29
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 64..182
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 195..320
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 349..467
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 585..700
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 712..830
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 843..964
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 981..1097
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
SQ SEQUENCE 1100 AA; 125644 MW; F5006B6C926D65D4 CRC64;
MNNEITYYFP CQRWLAVEED DGQLSRELLP VDESYVLPQS EEGRGGGDNN PLDNLALEQK
DKSTTFSVTI KTGVKKNAGT DANVFITLFG TQDDTGMTLL KSSKTNSDKF ERDSIEIFTV
ETLDLGDLWK VRLGHDNTGK APGWFVDWVE VDAPSLGKCM TFPCGRWLAK NEDDGSIIRD
LFHAELQTRL YTPFVPYEIT LYTSDVFAAG TDANIFIIIY GCDAVCTQQK YLCTNKREQK
QFFERKSASR FIVELEDVGE IIEKIRIGHN NTGMNPGWHC SHVDIRRLLP DKDGAETLTF
PCDRWLATSE DDKKTIRELV PYDIFTEKYM KDGSLRQVYK EVEEPLDIVL YSVQIFTGNI
PGAGTDAKVY ITIYGDLGDT GERYLGKSEN RTNKFERGTA DTFIIEAADL GVIYKIKLRH
DNSKWCADWY VEKVEIWNDT NEDEFLFLCG RWLSLKKEDG RLERLFYEKE YTGDRSSNCS
SPADFWEIAL SSKMADVDIS TVTGPMADYV QEGPIIPYYV SVTTGKHKDA ATDSRAFIFL
IGEDDERSKR IWLDYPRGKR GFSRGSVEEF YVAGLDVGII KKIEVLYEMT VWTGDVVGGG
TDSNIFMTLY GINGSTEEMQ LDKKKARFER EQNDTFIMEI LDIAPFTKMR IRIDGLGSRP
EWFLERILLK NMNTGDLTMF YYGDWLSQRK GKKTLVCEMC AVIDEEEMME WTSYTVAVKT
SDILGAGTDA NVFIIIFGEN GDSGTLALKQ SANWNKFERN NTDTFNFPDM LSLGHLCKLR
VWHDNKGIFP GWHLSYVDVK DNSRDETFHF QCDCWLSKSE GDGQTVRDFA CANNKICDEL
EETTYEIVIE TGNGGETREN VWLILEGRKN RSKEFLMENS SRQRAFRKGT TDTFEFDSIY
LGDIASLCVG HLAREDRFIP KRELAWHVKT ITITEMEYGN VYFFNCDCLI PLKRKRKYFK
VFEVTKTTES FASKVQSLVP VKYEVIVTTG YEPGAGTDAN VFVTIFGANG DTGKRELKQK
MRNLFERGST DRFFLETLEL GELRKVRLEH DSSGYCSGWL VEKVEVTNTS TGVATIFNCG
RWLDKKRGDG LTWRDLFPSV
//
