ID J3KTM9_HUMAN Unreviewed; 690 AA.
AC J3KTM9;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Karyopherin subunit beta 1 {ECO:0000313|Ensembl:ENSP00000463066.1};
DE Flags: Fragment;
GN Name=KPNB1 {ECO:0000313|Ensembl:ENSP00000463066.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000463066.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000463066.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2] {ECO:0007829|PubMed:19608861}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [3] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [4] {ECO:0007829|PubMed:24275569}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [5] {ECO:0007829|PubMed:25944712}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [6] {ECO:0000313|Ensembl:ENSP00000463066.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AC015674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC025682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF456283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF570270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MetOSite; J3KTM9; -.
DR MassIVE; J3KTM9; -.
DR MaxQB; J3KTM9; -.
DR PeptideAtlas; J3KTM9; -.
DR Antibodypedia; 17751; 354 antibodies from 41 providers.
DR Ensembl; ENST00000582097.5; ENSP00000463066.1; ENSG00000108424.11.
DR UCSC; uc060gpi.1; human.
DR HGNC; HGNC:6400; KPNB1.
DR VEuPathDB; HostDB:ENSG00000108424; -.
DR GeneTree; ENSGT00550000074898; -.
DR HOGENOM; CLU_008296_0_0_1; -.
DR ChiTaRS; KPNB1; human.
DR Proteomes; UP000005640; Chromosome 17.
DR Bgee; ENSG00000108424; Expressed in buccal mucosa cell and 215 other cell types or tissues.
DR ExpressionAtlas; J3KTM9; baseline and differential.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0031965; C:nuclear membrane; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR040122; Importin_beta.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR PANTHER; PTHR10527:SF1; IMPORTIN SUBUNIT BETA-1; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR SMART; SM00185; ARM; 3.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:J3KTM9,
KW ECO:0007829|MaxQB:J3KTM9};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT REPEAT 223..260
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000463066.1"
SQ SEQUENCE 690 AA; 76562 MW; 065BE4410A14ADE8 CRC64;
XACAEIPVNQ WPELIPQLVA NVTNPNSTEH MKESTLEAIG YICQDIDPEQ LQDKSNEILT
AIIQGMRKEE PSNNVKLAAT NALLNSLEFT KANFDKESER HFIMQVVCEA TQCPDTRVRV
AALQNLVKIM SLYYQYMETY MGPALFADEN DDDDDWNPCK AAGVCLMLLA TCCEDDIVPH
VLPFIKEHIK NPDWRYRDAA VMAFGCILEG PEPSQLKPLV IQAMPTLIEL MKDPSVVVRD
TAAWTVGRIC ELLPEAAIND VYLAPLLQCL IEGLSAEPRV ASNVCWAFSS LAEAAYEAAD
VADDQEEPAT YCLSSSFELI VQKLLETTDR PDGHQNNLRS SAYESLMEIV KNSAKDCYPA
VQKTTLVIME RLQQVLQMES HIQSTSDRIQ FNDLQSLLCA TLQNVLRKVQ HQDALQISDV
VMASLLRMFQ STAGSGGVQE DALMAVSTLV EVLGGEFLKY MEAFKPFLGI GLKNYAEYQV
CLAAVGLVGD LCRALQSNII PFCDEVMQLL LENLGNENVH RSVKPQILSV FGDIALAIGG
EFKKYLEVVL NTLQQASQAQ VDKSDYDMVD YLNELRESCL EAYTGIVQGL KGDQENVHPD
VMLVQPRVEF ILSFIDHIAG DEDHTDGVVA CAAGLIGDLC TAFGKDVLKL VEARPMIHEL
LTEGRRSKTN KAKTLATWAT KELRKLKNQA
//
