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Database: UniProt
Entry: J3N3C6_ORYBR
LinkDB: J3N3C6_ORYBR
Original site: J3N3C6_ORYBR 
ID   J3N3C6_ORYBR            Unreviewed;       975 AA.
AC   J3N3C6;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   28-MAR-2018, entry version 28.
DE   RecName: Full=Non-lysosomal glucosylceramidase {ECO:0000256|PIRNR:PIRNR028944};
DE            Short=NLGase {ECO:0000256|PIRNR:PIRNR028944};
DE            EC=3.2.1.45 {ECO:0000256|PIRNR:PIRNR028944};
GN   Name=102720741 {ECO:0000313|EnsemblPlants:OB10G20240.1};
OS   Oryza brachyantha (malo sina).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX   NCBI_TaxID=4533 {ECO:0000313|EnsemblPlants:OB10G20240.1};
RN   [1] {ECO:0000313|EnsemblPlants:OB10G20240.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IRGC 101232 {ECO:0000313|EnsemblPlants:OB10G20240.1};
RX   PubMed=23481403;
RA   Chen J., Huang Q., Gao D., Wang J., Lang Y., Liu T., Li B., Bai Z.,
RA   Luis Goicoechea J., Liang C., Chen C., Zhang W., Sun S., Liao Y.,
RA   Zhang X., Yang L., Song C., Wang M., Shi J., Liu G., Liu J., Zhou H.,
RA   Zhou W., Yu Q., An N., Chen Y., Cai Q., Wang B., Liu B., Min J.,
RA   Huang Y., Wu H., Li Z., Zhang Y., Yin Y., Song W., Jiang J.,
RA   Jackson S.A., Wing R.A., Wang J., Chen M.;
RT   "Whole-genome sequencing of Oryza brachyantha reveals mechanisms
RT   underlying Oryza genome evolution.";
RL   Nat. Commun. 4:1595-1595(2013).
RN   [2] {ECO:0000313|EnsemblPlants:OB10G20240.1}
RP   IDENTIFICATION.
RG   EnsemblPlants;
RL   Submitted (APR-2013) to UniProtKB.
CC   -!- FUNCTION: Non-lysosomal glucosylceramidase that catalyzes the
CC       conversion of glucosylceramide to free glucose and ceramide.
CC       {ECO:0000256|PIRNR:PIRNR028944}.
CC   -!- CATALYTIC ACTIVITY: D-glucosyl-N-acylsphingosine + H(2)O = D-
CC       glucose + N-acylsphingosine. {ECO:0000256|PIRNR:PIRNR028944}.
CC   -!- SIMILARITY: Belongs to the non-lysosomal glucosylceramidase
CC       family. {ECO:0000256|PIRNR:PIRNR028944}.
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DR   RefSeq; XP_006661858.2; XM_006661795.2.
DR   STRING; 4533.OB10G20240.1; -.
DR   EnsemblPlants; OB10G20240.1; OB10G20240.1; OB10G20240.
DR   GeneID; 102720741; -.
DR   Gramene; OB10G20240.1; OB10G20240.1; OB10G20240.
DR   KEGG; obr:102720741; -.
DR   eggNOG; KOG2119; Eukaryota.
DR   eggNOG; COG4354; LUCA.
DR   KO; K17108; -.
DR   OMA; FMEAMRM; -.
DR   OrthoDB; EOG09360216; -.
DR   Proteomes; UP000006038; Chromosome 10.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004348; F:glucosylceramidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006680; P:glucosylceramide catabolic process; IEA:InterPro.
DR   Gene3D; 1.50.10.10; -; 1.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR014551; B_Glucosidase_GBA2-typ.
DR   InterPro; IPR006775; GH116_catalytic.
DR   InterPro; IPR024462; GH116_N.
DR   Pfam; PF04685; DUF608; 1.
DR   Pfam; PF12215; Glyco_hydr_116N; 1.
DR   PIRSF; PIRSF028944; Beta_gluc_GBA2; 1.
DR   SUPFAM; SSF48208; SSF48208; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006038};
KW   Glycosidase {ECO:0000256|PIRNR:PIRNR028944};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR028944};
KW   Lipid metabolism {ECO:0000256|PIRNR:PIRNR028944};
KW   Membrane {ECO:0000256|PIRNR:PIRNR028944};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006038}.
FT   DOMAIN      102    422       Glyco_hydr_116N. {ECO:0000259|Pfam:
FT                                PF12215}.
FT   DOMAIN      558    919       DUF608. {ECO:0000259|Pfam:PF04685}.
SQ   SEQUENCE   975 AA;  109357 MW;  85934ECF0495F397 CRC64;
     MVSSNLFHCR RNSWPAEEYV GRTALQLLDF DGGSPPEQAW RRRLNSHANL LKEFSVTFME
     AMRMMSLGLR LWSYVREEAS HGRKAPIDPF TKEKCKPSAS QGVPLGGMGS GSISRGFRGE
     FKNWHIIPGL CETSPVMENQ FSIFVSRDGG NKKFSSVLSP GHHEGLRKCN DDSGISSWDW
     NLSGQHSTYH ALFPRAWTVY DGEPDPDLKI SCRQISPFIP HDYKDSSLPT SVFVYTLVNT
     GKDRAKVSLL MTWANSIGGF SHHSGGHFNE PFIAEDGVSG VLLHHKTAKD NPPVTFAIAA
     CETQNVNVTV LPVFGLSGEG QVSAKQMWDK MAQNGHFERE NFEAGSSMPS SSGETLCAAV
     SASTWVEPHG RCTVVFGLAW SSPKIKFQKG CTYNRRYTEF YGTSERSAVN LVHDALTKYK
     IWEEEIEKWQ NPILKNERLP EWYKFTLFNE LYFLVAGGTV WTDGQPPMID EKTNPGSNQQ
     KSSKRGTRDN KQESVKDNHV KLTAEQVANG GDLTDGEERS VSKYAAVHGS QMVEPTNGLG
     PQEPIPYLLS KKGPENVGKF LYLEGVEYIM WCTYDVHFYA SFALLDLFPK IELSIQRDFA
     NAVLYEDRRR MKFLADGTSG IRKVKGAVPH DLGTHDPWHE MNAYNIHDTS KWKDLNPKFV
     LQVYRDFAAT GDMSFGRDVW PAVCAAMDYM DQFDRDGDGL IENDGFPDQT YDAWTVHGIS
     AYCGGLWLAA LQAAATMAHR LGDRAFAEKY KLKFIKAKAV YEAKLWNGSY FNYDSGTSSN
     SRSIQADQLA GQWYAASSGL PPLFDEQKIR SALQKIFEFN VMKVKGGRLG AVNGMTPSGK
     VDETCMQSRE IWTGVTYGVA ANMLLHGMEH QAFTTAEGIF IAGWSEDGYG YWFQTPEGWT
     MDGHYRSLIY MRPLAVWAMQ WALSPPKAIL DAPKVNLMDR IHLSPQMIRA MNEISVRKIA
     PDNRCFPSSA FRCQC
//
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