ID J3QKM0_HUMAN Unreviewed; 202 AA.
AC J3QKM0;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Rho GTPase activating protein 28 {ECO:0000313|Ensembl:ENSP00000463143.1};
DE Flags: Fragment;
GN Name=ARHGAP28 {ECO:0000313|Ensembl:ENSP00000463143.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000463143.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000463143.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A.,
RA Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q.,
RA Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [2] {ECO:0000313|Ensembl:ENSP00000463143.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP005205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP005210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; J3QKM0; -.
DR SMR; J3QKM0; -.
DR MassIVE; J3QKM0; -.
DR PeptideAtlas; J3QKM0; -.
DR Antibodypedia; 21924; 127 antibodies from 23 providers.
DR Ensembl; ENST00000579689.1; ENSP00000463143.1; ENSG00000088756.13.
DR UCSC; uc060nct.1; human.
DR HGNC; HGNC:25509; ARHGAP28.
DR VEuPathDB; HostDB:ENSG00000088756; -.
DR GeneTree; ENSGT00940000158929; -.
DR HOGENOM; CLU_1357388_0_0_1; -.
DR ChiTaRS; ARHGAP28; human.
DR Proteomes; UP000005640; Chromosome 18.
DR Bgee; ENSG00000088756; Expressed in sperm and 134 other cell types or tissues.
DR ExpressionAtlas; J3QKM0; baseline and differential.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR PANTHER; PTHR14963:SF5; RHO GTPASE-ACTIVATING PROTEIN 28; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:J3QKM0,
KW ECO:0007829|MaxQB:J3QKM0};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 12..202
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000463143.1"
FT NON_TER 202
FT /evidence="ECO:0000313|Ensembl:ENSP00000463143.1"
SQ SEQUENCE 202 AA; 23213 MW; 040DEB3A48C9F3BB CRC64;
EDMKKIRHLS LIELTAFFDA FGIQLKRNKT EKVKGRDNGI FGVPLTVLLD GDRKKDPGVK
VPLVLQKQYR EELDAKFNAD KFKWDKMCHR EAAVMLKAFF RELPTSLFPV EYIPAFISLM
ERGPHVKVQF QALHLMVMAL PDANRDAAQA LMTFFNKVIA NESKNRMSLW NISTVMAPNL
FFSRSKHSDY EELLLANTAA HI
//
