ID J3QQZ2_HUMAN Unreviewed; 328 AA.
AC J3QQZ2;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=RNA binding protein fox-1 homolog 3 {ECO:0000256|PIRNR:PIRNR037932};
GN Name=RBFOX3 {ECO:0000313|Ensembl:ENSP00000463964.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000463964.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000463964.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000463964.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: RNA-binding protein that regulates alternative splicing
CC events. {ECO:0000256|PIRNR:PIRNR037932}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR037932}.
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DR EMBL; AC020689; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC021534; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC055858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC073624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC233701; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF570271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; J3QQZ2; -.
DR SMR; J3QQZ2; -.
DR MassIVE; J3QQZ2; -.
DR MaxQB; J3QQZ2; -.
DR PeptideAtlas; J3QQZ2; -.
DR Antibodypedia; 32645; 598 antibodies from 38 providers.
DR Ensembl; ENST00000582043.5; ENSP00000463964.1; ENSG00000167281.20.
DR UCSC; uc060kyz.1; human.
DR HGNC; HGNC:27097; RBFOX3.
DR VEuPathDB; HostDB:ENSG00000167281; -.
DR GeneTree; ENSGT00940000159924; -.
DR ChiTaRS; RBFOX3; human.
DR Proteomes; UP000005640; Chromosome 17.
DR Bgee; ENSG00000167281; Expressed in right hemisphere of cerebellum and 117 other cell types or tissues.
DR ExpressionAtlas; J3QQZ2; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:InterPro.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR025670; Fox-1_C_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR017325; RBFOX1-3.
DR InterPro; IPR047131; RBFOX1-like.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR15597; ATAXIN 2-BINDING PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR15597:SF25; RNA BINDING PROTEIN FOX-1 HOMOLOG 3; 1.
DR Pfam; PF12414; Fox-1_C; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF037932; Ataxin_2_bd_A2BP; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
PE 1: Evidence at protein level;
KW mRNA processing {ECO:0000256|PIRNR:PIRNR037932};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187,
KW ECO:0000256|PIRNR:PIRNR037932}; Nucleus {ECO:0000256|PIRNR:PIRNR037932};
KW Proteomics identification {ECO:0007829|PeptideAtlas:J3QQZ2,
KW ECO:0007829|ProteomicsDB:J3QQZ2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW RNA-binding {ECO:0000256|PIRNR:PIRNR037932, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 99..136
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..33
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 328 AA; 35443 MW; 440FF75DECD57FA7 CRC64;
MAQPYPPAQY PPPPQNGIPA EYAPPPPHPT QDYSGQTPVP TEHGMTLYTP AQTHPEQPGS
EASTQPIAGT QTVPQTDEAA QTDSQPLHPS DPTEKQQPKR LHVSNIPFRF RDPDLRQMFG
QFGKILDVEI IFNERGSKVN NATARVMTNK KTGNPYTNGW KLNPVVGAVY GPEFYAVTGF
PYPTTGTAVA YRGAHLRGRG RAVYNTFRAA PPPPPIPTYG AALEQTLVKM PVPWAGLAPC
PLPPQQTPEP AYPTSPAFPP LSCPFASRVV YQDGFYGAEI YGGYAAYRYA QPAAAAAAYS
DSYGRVYAAA DPYHHTIGPA ATYSIGTM
//
