ID J3QRK1_HUMAN Unreviewed; 260 AA.
AC J3QRK1;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Potassium channel tetramerization domain containing 1 {ECO:0000313|Ensembl:ENSP00000464261.1};
DE Flags: Fragment;
GN Name=KCTD1 {ECO:0000313|Ensembl:ENSP00000464261.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000464261.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000464261.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A.,
RA Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q.,
RA Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [2] {ECO:0007829|PubMed:18669648}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [3] {ECO:0007829|PubMed:23186163}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23186163;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [4] {ECO:0000313|Ensembl:ENSP00000464261.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC007996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC012588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC090206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF456360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; J3QRK1; -.
DR SMR; J3QRK1; -.
DR MassIVE; J3QRK1; -.
DR MaxQB; J3QRK1; -.
DR PeptideAtlas; J3QRK1; -.
DR Antibodypedia; 54340; 121 antibodies from 12 providers.
DR Ensembl; ENST00000580191.5; ENSP00000464261.1; ENSG00000134504.14.
DR UCSC; uc060odn.1; human.
DR HGNC; HGNC:18249; KCTD1.
DR VEuPathDB; HostDB:ENSG00000134504; -.
DR GeneTree; ENSGT00940000156453; -.
DR ChiTaRS; KCTD1; human.
DR Proteomes; UP000005640; Chromosome 18.
DR Bgee; ENSG00000134504; Expressed in oviduct epithelium and 177 other cell types or tissues.
DR ExpressionAtlas; J3QRK1; baseline and differential.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR CDD; cd18387; BTB_POZ_KCTD1; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR048599; BTB_POZ_KCTD1.
DR InterPro; IPR048595; KCTD1-15-like_C.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR PANTHER; PTHR14499:SF65; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD1; 1.
DR PANTHER; PTHR14499; POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF20871; KCTD1-15_CTD; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:J3QRK1,
KW ECO:0007829|MaxQB:J3QRK1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 38..140
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 260
FT /evidence="ECO:0000313|Ensembl:ENSP00000464261.1"
SQ SEQUENCE 260 AA; 29798 MW; E13A5E44CBC42253 CRC64;
MFQDSRPNMS RPLITRSPAS PLNNQGIPTP AQLTKSNAPV HIDVGGHMYT SSLATLTKYP
ESRIGRLFDG TEPIVLDSLK QHYFIDRDGQ MFRYILNFLR TSKLLIPDDF KDYTLLYEEA
KYFQLQPMLL EMERWKQDRE TGRFSRPCEC LVVRVAPDLG ERITLSGDKS LIEEVFPEIG
DVMCNSVNAG WNHDSTHVIR FPLNGYCHLN SVQVLERLQQ RGFEIVGSCG GGVDSSQFSE
YVLRRELRRT PRVPSVIRIK
//
