ID   J3QRP9_HUMAN            Unreviewed;       103 AA.
AC   J3QRP9;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 70.
DE   SubName: Full=GRB2 related adaptor protein {ECO:0000313|Ensembl:ENSP00000464328.1};
GN   Name=GRAP {ECO:0000313|Ensembl:ENSP00000464328.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000464328.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000464328.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000464328.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AC003957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_011522159.1; XM_011523857.2.
DR   AlphaFoldDB; J3QRP9; -.
DR   SMR; J3QRP9; -.
DR   MassIVE; J3QRP9; -.
DR   PeptideAtlas; J3QRP9; -.
DR   DNASU; 400581; -.
DR   Ensembl; ENST00000583020.1; ENSP00000464328.1; ENSG00000154016.14.
DR   GeneID; 400581; -.
DR   UCSC; uc060chy.1; human.
DR   CTD; 400581; -.
DR   HGNC; HGNC:4562; GRAP.
DR   VEuPathDB; HostDB:ENSG00000154016; -.
DR   GeneTree; ENSGT00940000156254; -.
DR   HOGENOM; CLU_181912_0_0_1; -.
DR   OrthoDB; 25371at2759; -.
DR   BioGRID-ORCS; 400581; 13 hits in 690 CRISPR screens.
DR   ChiTaRS; GRAP; human.
DR   GenomeRNAi; 400581; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000154016; Expressed in spleen and 101 other cell types or tissues.
DR   ExpressionAtlas; J3QRP9; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IEA:UniProt.
DR   CDD; cd11948; SH3_GRAP_N; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR035645; GRAP_N_SH3.
DR   InterPro; IPR043539; Grb2-like.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR46037:SF2; GRB2-RELATED ADAPTER PROTEIN; 1.
DR   PANTHER; PTHR46037; PROTEIN ENHANCER OF SEVENLESS 2B; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          1..58
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          60..103
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
SQ   SEQUENCE   103 AA;  11911 MW;  508F11EB2493B21B CRC64;
     MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGVEGFIPK NYIRVKPHPW
     YSGRISRQLA EEILMKRNHL GAFLIRESES SPGEFSVSVK WAN
//