ID   J4C3M4_THEOR            Unreviewed;       840 AA.
AC   J4C3M4;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   13-SEP-2023, entry version 39.
DE   RecName: Full=UmuC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=TOT_020000950 {ECO:0000313|EMBL:BAM40696.1};
OS   Theileria orientalis strain Shintoku.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Theileriidae; Theileria.
OX   NCBI_TaxID=869250 {ECO:0000313|EMBL:BAM40696.1, ECO:0000313|Proteomes:UP000003786};
RN   [1] {ECO:0000313|EMBL:BAM40696.1, ECO:0000313|Proteomes:UP000003786}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shintoku {ECO:0000313|EMBL:BAM40696.1,
RC   ECO:0000313|Proteomes:UP000003786};
RX   PubMed=22951932;
RA   Hayashida K., Hara Y., Abe T., Yamasaki C., Toyoda A., Kosuge T.,
RA   Suzuki Y., Sato Y., Kawashima S., Katayama T., Wakaguri H., Inoue N.,
RA   Homma K., Tada-Umezaki M., Yagi Y., Fujii Y., Habara T., Kanehisa M.,
RA   Watanabe H., Ito K., Gojobori T., Sugawara H., Imanishi T., Weir W.,
RA   Gardner M., Pain A., Shiels B., Hattori M., Nene V., Sugimoto C.;
RT   "Comparative genome analysis of three eukaryotic parasites with differing
RT   abilities to transform leukocytes reveals key mediators of Theileria-
RT   induced leukocyte transformation.";
RL   MBio 3:e00204-e00212(2012).
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC       {ECO:0000256|ARBA:ARBA00010945}.
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DR   EMBL; AP011947; BAM40696.1; -; Genomic_DNA.
DR   RefSeq; XP_009690997.1; XM_009692702.1.
DR   AlphaFoldDB; J4C3M4; -.
DR   STRING; 869250.J4C3M4; -.
DR   EnsemblProtists; BAM40696; BAM40696; TOT_020000950.
DR   GeneID; 20715056; -.
DR   KEGG; tot:TOT_020000950; -.
DR   VEuPathDB; PiroplasmaDB:TOT_020000950; -.
DR   eggNOG; KOG2093; Eukaryota.
DR   OrthoDB; 232520at2759; -.
DR   Proteomes; UP000003786; Chromosome 2.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.40.1170.60; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.40.50.10190; BRCT domain; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR001126; UmuC.
DR   Pfam; PF00817; IMS; 1.
DR   SUPFAM; SSF52113; BRCT domain; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50172; BRCT; 1.
DR   PROSITE; PS50173; UMUC; 1.
PE   3: Inferred from homology;
KW   DNA synthesis {ECO:0000256|ARBA:ARBA00022634};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003786}.
FT   DOMAIN          53..165
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          253..444
FT                   /note="UmuC"
FT                   /evidence="ECO:0000259|PROSITE:PS50173"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          175..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          515..576
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          688..717
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          741..840
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        699..717
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        741..775
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        776..794
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        817..840
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   840 AA;  95243 MW;  EE58468AE1C0BA1A CRC64;
     MDHKEISKSH TFSENESKSS KLETKEIQSR DMAESRDMAE SGDMAESGDR KVKYKKIFKD
     CYFCIGDVSR SYREYFEACK GRCSVSVVSF RNRLIDIVLK RGGGLEASLS PYVTHFVVER
     AGASERWWIR RRAKGTPKKY HFVTAKYVVE SHMKGKRLHE SSYVPKFLKT PGVLILPPSN
     EGTPDRGESE PSTPSPRGES YRIMESWAQT LEAEELEDFK SMDVGIYMNG NIVYIYMENF
     LVETLVVEGL RVPAAVYSCD QVISVNAQGT EAGIRKGMHV KTARSKGVAD LRLAKYNYEK
     VVERGLSVVR FLREYTTHIL SPYYNEFYLQ LSYERARELL GESGSKEDDK ENMRKLAAKI
     YAEFPGECVM GLGKNMLIAK LAAKKCRNLK VNSQESDYDY EMSPVLSIYG INGGESLVSE
     NICVVDDGFK FLNNVHLSEI PGVGVLWPVL KSRGLLTCND VRKKGTPLCL QSILGGRMGK
     MVYNFCFGYD YRCSNLPKKQ LDFFLNKSFR TRSRVPSAHV RRSQPSQRSQ PNECSQRSQP
     NECSQRSQPN ESSQRSQPNE SSQRNRPNDQ RSQQSEESIF KKMLTDILKQ LCSVYSLFDR
     CIINYSIKYK CTVVVKVTGK EEYSRCVSSI LDKESLRHTT QKLYSEIKEE LGPELSDMLT
     IQIEVKDIVR VDENIKFIDN FLTGKSQSSQ RSMSRIKEED ANNGTNSSSN NGSNMASEVM
     CTPTRRFNGW RLDSILSVSE AQEDSNKAEN SNGSSNNWSL NSHKSSASPH SVPSSKSADS
     RRRTPTRRKA ESSVDTNQRS SSRSRKLGRV TEGQKYITEY ISPTRSESKE GNKQLESSTL
//