ID   J4DNZ4_THEOR            Unreviewed;       506 AA.
AC   J4DNZ4;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=Peptidase C1A papain C-terminal domain-containing protein {ECO:0000259|SMART:SM00645};
GN   ORFNames=TOT_020000085 {ECO:0000313|EMBL:BAM39814.1};
OS   Theileria orientalis strain Shintoku.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Theileriidae; Theileria.
OX   NCBI_TaxID=869250 {ECO:0000313|EMBL:BAM39814.1, ECO:0000313|Proteomes:UP000003786};
RN   [1] {ECO:0000313|EMBL:BAM39814.1, ECO:0000313|Proteomes:UP000003786}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shintoku {ECO:0000313|EMBL:BAM39814.1,
RC   ECO:0000313|Proteomes:UP000003786};
RX   PubMed=22951932;
RA   Hayashida K., Hara Y., Abe T., Yamasaki C., Toyoda A., Kosuge T.,
RA   Suzuki Y., Sato Y., Kawashima S., Katayama T., Wakaguri H., Inoue N.,
RA   Homma K., Tada-Umezaki M., Yagi Y., Fujii Y., Habara T., Kanehisa M.,
RA   Watanabe H., Ito K., Gojobori T., Sugawara H., Imanishi T., Weir W.,
RA   Gardner M., Pain A., Shiels B., Hattori M., Nene V., Sugimoto C.;
RT   "Comparative genome analysis of three eukaryotic parasites with differing
RT   abilities to transform leukocytes reveals key mediators of Theileria-
RT   induced leukocyte transformation.";
RL   MBio 3:e00204-e00212(2012).
CC   -!- SIMILARITY: Belongs to the peptidase C1 family.
CC       {ECO:0000256|ARBA:ARBA00008455}.
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DR   EMBL; AP011947; BAM39814.1; -; Genomic_DNA.
DR   RefSeq; XP_009690115.1; XM_009691820.1.
DR   AlphaFoldDB; J4DNZ4; -.
DR   STRING; 869250.J4DNZ4; -.
DR   EnsemblProtists; BAM39814; BAM39814; TOT_020000085.
DR   GeneID; 20714267; -.
DR   KEGG; tot:TOT_020000085; -.
DR   VEuPathDB; PiroplasmaDB:TOT_020000085; -.
DR   eggNOG; KOG1543; Eukaryota.
DR   OrthoDB; 5472948at2759; -.
DR   Proteomes; UP000003786; Chromosome 2.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd02248; Peptidase_C1A; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR025661; Pept_asp_AS.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR013128; Peptidase_C1A.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   InterPro; IPR039417; Peptidase_C1A_papain-like.
DR   InterPro; IPR013201; Prot_inhib_I29.
DR   PANTHER; PTHR12411:SF741; CATHEPSIN K; 1.
DR   PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR   Pfam; PF08246; Inhibitor_I29; 1.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   PRINTS; PR00705; PAPAIN.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003786};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT   TRANSMEM        26..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          278..494
FT                   /note="Peptidase C1A papain C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00645"
SQ   SEQUENCE   506 AA;  58181 MW;  F5CEDE4D4FF76F71 CRC64;
     MKELDVERQI FQNETRKCRI KKCLSIGTLI VVIILVASII STLIFFGVKG PKSKKYDKII
     PLQLPLVERI NVIEQPSVVI KADSPKDFEV PPPVVPKLHV DPDPDPKIVP EVKRILKANP
     VEVMKKESIM THFVEIARNK KVEIIEGDFE TCAAGNCGTH DGEFVHEWKL KAVSEDLKVQ
     SPTELEDEFD KIIKYDRHNL QYGKYYSDVL TYNQTFKIFK KNIEIVETHN KNPKRLYDMK
     LNMFAAYAED FGDMTYYPIK NPLFTVPKTA GVIEDFDQVI DVDWRKKDAV TDVIAQGGCG
     SCWAIAATDM FNSFMMIKKG SQFEMSYQQV LDCTDRSFTC QRGGNHGKAL EYIKKNKICL
     NSEKEYKGHM DTCDVRDCKL SSEIEKIKRM NHDESLEYLK EKGPFLTSFE TNTSFLLYDD
     GIYDGSCENG RGHSIVVVGH GHDTKKKVDY WIVKNSWGKD WGEDGYFRII DSSKMDGNVK
     RYHCDFTLQS YGWIRSKSKN GKNNEY
//