ID   J4DQ67_THEOR            Unreviewed;      1070 AA.
AC   J4DQ67;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=PA14 domain-containing protein {ECO:0000259|PROSITE:PS51820};
GN   ORFNames=TOT_040000304 {ECO:0000313|EMBL:BAM41924.1};
OS   Theileria orientalis strain Shintoku.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Theileriidae; Theileria.
OX   NCBI_TaxID=869250 {ECO:0000313|EMBL:BAM41924.1, ECO:0000313|Proteomes:UP000003786};
RN   [1] {ECO:0000313|EMBL:BAM41924.1, ECO:0000313|Proteomes:UP000003786}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shintoku {ECO:0000313|EMBL:BAM41924.1,
RC   ECO:0000313|Proteomes:UP000003786};
RX   PubMed=22951932;
RA   Hayashida K., Hara Y., Abe T., Yamasaki C., Toyoda A., Kosuge T.,
RA   Suzuki Y., Sato Y., Kawashima S., Katayama T., Wakaguri H., Inoue N.,
RA   Homma K., Tada-Umezaki M., Yagi Y., Fujii Y., Habara T., Kanehisa M.,
RA   Watanabe H., Ito K., Gojobori T., Sugawara H., Imanishi T., Weir W.,
RA   Gardner M., Pain A., Shiels B., Hattori M., Nene V., Sugimoto C.;
RT   "Comparative genome analysis of three eukaryotic parasites with differing
RT   abilities to transform leukocytes reveals key mediators of Theileria-
RT   induced leukocyte transformation.";
RL   MBio 3:e00204-e00212(2012).
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DR   EMBL; AP011949; BAM41924.1; -; Genomic_DNA.
DR   RefSeq; XP_009692225.1; XM_009693930.1.
DR   AlphaFoldDB; J4DQ67; -.
DR   EnsemblProtists; BAM41924; BAM41924; TOT_040000304.
DR   GeneID; 20716379; -.
DR   KEGG; tot:TOT_040000304; -.
DR   VEuPathDB; PiroplasmaDB:TOT_040000304; -.
DR   eggNOG; ENOG502QVHV; Eukaryota.
DR   OrthoDB; 196764at2759; -.
DR   Proteomes; UP000003786; Chromosome 4.
DR   Gene3D; 2.10.10.10; Fibronectin, type II, collagen-binding; 1.
DR   Gene3D; 3.90.182.10; Toxin - Anthrax Protective Antigen;domain 1; 1.
DR   InterPro; IPR036943; FN_type2_sf.
DR   InterPro; IPR037524; PA14/GLEYA.
DR   InterPro; IPR011658; PA14_dom.
DR   Pfam; PF07691; PA14; 1.
DR   SMART; SM00758; PA14; 1.
DR   SUPFAM; SSF56988; Anthrax protective antigen; 1.
DR   PROSITE; PS51820; PA14; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003786};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..1070
FT                   /note="PA14 domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003778849"
FT   DOMAIN          311..472
FT                   /note="PA14"
FT                   /evidence="ECO:0000259|PROSITE:PS51820"
FT   REGION          50..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          218..298
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        50..113
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1070 AA;  121564 MW;  9A704CB154629E12 CRC64;
     MCKSTTYILC SVVFCIGLAS ANLFFQKNGP PVLDNTSNNV VKPQIQQVVP ENNGTQSTIS
     NYSPNVNTPN NYDANFNKND TSNNVYDNLN NTVDQPAQNN NNESVNQTQD SSDNTEDESS
     EENDNELMYY LTQYRNRARR TIEGHLCAAA FVQRDQIYTD CTVEVAPDGT EGSKEWCYLE
     AQLTGKLEKD WGFCETPLNY EEIRSATLNH IQQKVSQVDE LLKSLNTYRK LIKESERRLS
     TVCGMGHRFI SDSLSKIETV LEESEKRIDD VNKLKNEIER IKNEIKKIQC VHNEVRKSQS
     TKYYPDNDIY NVSDGLVGTY YSNNVFEFPA VANRVDPQIN FSFVNKMPIL GLSPYKFSIR
     WEGYLKVPHS GNFVFELSTD AHGRVELNGT EIINTGIMFE GDDEIGYRFW VDPLMAKKEV
     SQAQQLIGGK FYKIKVEMSH SQQYKYDKGS ESYFKLLWSS RRIDKQVIPS TNFYSKFKKT
     HTSISRLPAS NFEIVNSFNG ESAFRGSNSV FVANLSNGLI GSQLIRSDEK YNMGSFKMNV
     NQDSMLYVGY KKGQPFPLNP KDEQQWIEEE TLESFDMYSA EALSENKVLS ALNKIFKNDK
     ESVLIETELK QIPLVRGVTY KFVTTNPDVS FVLFLSDNIN SKQNQCIGSE VLVSLPGGSH
     FMSCSESSAH SREYDCNAAL SGKYMDKKKS VWRTSGGTGE SISIIFREPV LVTEFKFRPR
     DSSYTWPSKI TLSYKEGGSE TFNIFHSNDL EHHSYRVSVP KITTSVKVTI DEMYVSGPET
     GGSFGILGIP CKFSENLRFV EIMKCSESLV DLQNIYTFKN NDKFLAECQQ ECLVKSRVYV
     RDFNASEDQR FNETDPICGC AVSNDYCHED SGSCVVEVQV VVNNGTGYLL RKSHHKQKKR
     MKKVQILFRK QPDKTPTQGY LIDNGQVKSD LDNLSYGWFR EAHGQFCSSN DNPLYGGGIQ
     FPPPTESLDC VQKEKCSGNY WSIELPENGD YKLEVILGSV CKLNHDFEAY LEVNGMPLVN
     GEVFKRDQFY TLVKNVTVKN KRIKLTSTCK NDQCPENGTI IQMVSVEQLV
//