ID   J4G0R1_9APHY            Unreviewed;       584 AA.
AC   J4G0R1;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=Thioredoxin domain-containing protein {ECO:0000259|PROSITE:PS51352};
GN   ORFNames=FIBRA_01011 {ECO:0000313|EMBL:CCL99003.1};
OS   Fibroporia radiculosa.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Polyporales; Fibroporiaceae; Fibroporia.
OX   NCBI_TaxID=599839 {ECO:0000313|EMBL:CCL99003.1, ECO:0000313|Proteomes:UP000006352};
RN   [1] {ECO:0000313|EMBL:CCL99003.1, ECO:0000313|Proteomes:UP000006352}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TFFH 294 {ECO:0000313|EMBL:CCL99003.1,
RC   ECO:0000313|Proteomes:UP000006352};
RX   PubMed=22247176; DOI=10.1128/AEM.06745-11;
RA   Tang J.D., Perkins A.D., Sonstegard T.S., Schroeder S.G., Burgess S.C.,
RA   Diehl S.V.;
RT   "Short-read sequencing for genomic analysis of the brown rot fungus
RT   Fibroporia radiculosa.";
RL   Appl. Environ. Microbiol. 78:2272-2281(2012).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004167}.
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DR   EMBL; HE796910; CCL99003.1; -; Genomic_DNA.
DR   RefSeq; XP_012178286.1; XM_012322896.1.
DR   AlphaFoldDB; J4G0R1; -.
DR   STRING; 599839.J4G0R1; -.
DR   GeneID; 24093914; -.
DR   HOGENOM; CLU_021868_1_1_1; -.
DR   InParanoid; J4G0R1; -.
DR   OrthoDB; 52245at2759; -.
DR   Proteomes; UP000006352; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd02961; PDI_a_family; 2.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 3.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR017937; Thioredoxin_CS.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   PANTHER; PTHR46426; PROTEIN DISULFIDE-ISOMERASE TMX3; 1.
DR   PANTHER; PTHR46426:SF1; PROTEIN DISULFIDE-ISOMERASE TMX3; 1.
DR   Pfam; PF00085; Thioredoxin; 2.
DR   Pfam; PF13848; Thioredoxin_6; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 3.
DR   PROSITE; PS00194; THIOREDOXIN_1; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006352};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..584
FT                   /note="Thioredoxin domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003778024"
FT   TRANSMEM        542..561
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          9..134
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000259|PROSITE:PS51352"
FT   DOMAIN          146..283
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000259|PROSITE:PS51352"
FT   REGION          133..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        138..154
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   584 AA;  64900 MW;  4FE06AE18516E22E CRC64;
     MLARLPYTLL ATALAVAVQA LPVDSTELTV LTPDNFESTI SEGVWFIEHF SPYCGHCRKF
     LPTWTQLVEN NAKQADPGIR LAQVNCAING DLCSKNGVDG YPQMNLYRNG QFVESYGDSR
     EYELLTAYLS SHAEPTSKPK LPPTPTPEPA PIPHAEEPSQ DGKYDPIPEP ARDLNPRGAV
     LALTDKTFGD AIKEGTVFIK FYAPWCGHCK KLAPIWTQLA GKMQHKLTIA EVNCEAHDAL
     CRNEGVTGFP MLVYYGPNGG GKTEYTGGRK LEQLKAFSEK VIGPAIQEVK YEDLPSIMSE
     SPSLYLLLHP PSDSRTIREV LKASSVLFGS PPIYSSSSSF LYDYFSVQSN SAVILALKDH
     DDIPAAVYRI THSADENSAL SSWLLRNRLP SSMELDADNF QEVMNAPHKP LVVLIATPKD
     QMGVVSSAVQ KIARQWKDTK GDGAISFVWM DGEKWGKWLK SMYGIKADSL PRIVVANHAR
     LVYYDKDQFG EDIQLTSTSI FSAIHGAAGG TIPYKHSENM VERMARYLNA KLTATETYVF
     SYPWRTAFFI FLGIAVIILV FKRLFAADSD SREYSHMRKA DRLD
//