ID   J4I9X8_9APHY            Unreviewed;       929 AA.
AC   J4I9X8;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN   ORFNames=FIBRA_04009 {ECO:0000313|EMBL:CCM01936.1};
OS   Fibroporia radiculosa.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Polyporales; Fibroporiaceae; Fibroporia.
OX   NCBI_TaxID=599839 {ECO:0000313|EMBL:CCM01936.1, ECO:0000313|Proteomes:UP000006352};
RN   [1] {ECO:0000313|EMBL:CCM01936.1, ECO:0000313|Proteomes:UP000006352}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TFFH 294 {ECO:0000313|EMBL:CCM01936.1,
RC   ECO:0000313|Proteomes:UP000006352};
RX   PubMed=22247176; DOI=10.1128/AEM.06745-11;
RA   Tang J.D., Perkins A.D., Sonstegard T.S., Schroeder S.G., Burgess S.C.,
RA   Diehl S.V.;
RT   "Short-read sequencing for genomic analysis of the brown rot fungus
RT   Fibroporia radiculosa.";
RL   Appl. Environ. Microbiol. 78:2272-2281(2012).
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DR   EMBL; HE797057; CCM01936.1; -; Genomic_DNA.
DR   RefSeq; XP_012181219.1; XM_012325829.1.
DR   AlphaFoldDB; J4I9X8; -.
DR   STRING; 599839.J4I9X8; -.
DR   GeneID; 24096847; -.
DR   HOGENOM; CLU_314737_0_0_1; -.
DR   InParanoid; J4I9X8; -.
DR   OrthoDB; 53554at2759; -.
DR   Proteomes; UP000006352; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR12673:SF270; DH DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006352}.
FT   DOMAIN          500..767
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          1..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          123..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          276..333
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          431..500
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..52
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..68
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..105
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        133..147
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        155..169
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        218..246
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        276..298
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        432..486
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   929 AA;  101635 MW;  0026230769FFD89E CRC64;
     MPAPPAEPPS PRLTRTRTTP NRAHYEKNRS RSRQASGGSS RPTSSKGTQD SNNPSEREVR
     KMKSAGELRR NHPQLPQPPS KSAAPSPQRV AMSEYVTSAS SSNLLDVATS RDSQVLPKRF
     ASLGVAAGPS SPNHSRPRLT MDNSFWDSTP GEEDGEEDVL GKPMPRRATL SRDHPQAPQI
     DQDNALAQLP SPPPKDEKDK SRRWGFLKKM SMGKMRTDSS PRVPSTGRSP GPPYRQTLSR
     APSMTGTAPG VPQIDVRIST TGALLNAANH SLPPIPSDAP LPVLTEAPSP PPPQVPEKPY
     LDALKMPSSP SNLLAPTPTP RATKRRSFLP IDMSPIPIPT PSTFVRDVVA SGSSEDLEEV
     HKPALDPVVL QKEALEQMQR REEERIHEAR VRALRSVMAY LRDMHDLGLT YANVTPVDPL
     GGIRSRRPTV VESRLPSDTS LGSVVSVSST PSRPGSTAQL RSSESWSGLR TGSTTQTNSV
     ATTDSSGSGE ERKHKDDRGK RSKIIREIVE TERTYVKGLQ ELVDIYIDPA AATVSGLGNV
     GQKQETVVPA AERKVVFSGL EALFRFHKDS FLPALERASA SLLVSSEELA AKDADGYLSL
     DVAMKVAQIF VSHAAFMKMY STYINNFDNS VQRIKMWTLD RPPTSSGQTL SPSSSSAQLA
     GLGISMSSIS VPGALQDSAA IQASTAVLTS SQRKRIKNYL KRCRLNPRHS QLNLEGYLLL
     PVQRIPRYRL LLEELVRSSP PMYDYVDDPL ERALAEISSL ANNMNEGKRE SESRRRLVQW
     QARIRGKFPS PLVQPHRRLI MDGPLHLTRV VRKATVSFEV IDAQGDTSEV QVECLSPELT
     PRSLIGILCN DLLVLCRDPS EGQDPGCAVD LWAVLRMQTL PQPASIVHGN ALRLVDNKAI
     LYFDAPSTSD ALTWFRGNVA APIGCEDEF
//