ID J4I9Y2_9APHY Unreviewed; 410 AA.
AC J4I9Y2;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=acetyl-CoA C-acyltransferase {ECO:0000256|ARBA:ARBA00024073};
DE EC=2.3.1.16 {ECO:0000256|ARBA:ARBA00024073};
GN ORFNames=FIBRA_04029 {ECO:0000313|EMBL:CCM01956.1};
OS Fibroporia radiculosa.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Fibroporiaceae; Fibroporia.
OX NCBI_TaxID=599839 {ECO:0000313|EMBL:CCM01956.1, ECO:0000313|Proteomes:UP000006352};
RN [1] {ECO:0000313|EMBL:CCM01956.1, ECO:0000313|Proteomes:UP000006352}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TFFH 294 {ECO:0000313|EMBL:CCM01956.1,
RC ECO:0000313|Proteomes:UP000006352};
RX PubMed=22247176; DOI=10.1128/AEM.06745-11;
RA Tang J.D., Perkins A.D., Sonstegard T.S., Schroeder S.G., Burgess S.C.,
RA Diehl S.V.;
RT "Short-read sequencing for genomic analysis of the brown rot fungus
RT Fibroporia radiculosa.";
RL Appl. Environ. Microbiol. 78:2272-2281(2012).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; HE797057; CCM01956.1; -; Genomic_DNA.
DR RefSeq; XP_012181239.1; XM_012325849.1.
DR AlphaFoldDB; J4I9Y2; -.
DR STRING; 599839.J4I9Y2; -.
DR GeneID; 24096867; -.
DR HOGENOM; CLU_031026_1_1_1; -.
DR InParanoid; J4I9Y2; -.
DR OrthoDB; 5481312at2759; -.
DR Proteomes; UP000006352; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR PANTHER; PTHR43853:SF10; ACETYL-COA C-ACETYLTRANSFERASE; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000006352};
KW Transferase {ECO:0000256|RuleBase:RU003557}.
FT DOMAIN 34..277
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 286..405
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 118
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 364
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 394
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 410 AA; 43144 MW; E836061D0A03257F CRC64;
MFSVGVRRGV TPLARSMATH ARVSTILEKK PEDVVITFAK RTPLGRAKKG QLKDFPADEL
MRALIAATLD KTKLDPAKID DICVGTCHPP SPAYISRAAA LAAGVPASVP VSTVNRLCGS
GLQAIRAIAT AVESRQMTLG MAIGVESMSQ NPRPTPEIVD AVDANPQAHD CVQPMGWTSE
MVAQVYNISR AKQDEYAFIS HSRAEKATAS GIFSEEIAPI EIRGTVISTD DTVRMGTTAE
GLAKLKPSFP NWGESSTTAG NASGLGDGAA LCIMTTRANA EKEGLEILGK YVTSSFVGVE
PRYMGIAPVV AIPQVLAQAG LSKEDVDVFE INEAFASQFA YCVEQLDVPI AKINPNGGSI
ALTHPLGMTG ARQVVTGLAE LRRRGGAILC TSMCIGSGMG GAGIFVNELR
//
