ID J4KRA6_BEAB2 Unreviewed; 825 AA.
AC J4KRA6;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=PA domain-containing protein {ECO:0000313|EMBL:EJP70619.1};
GN ORFNames=BBA_00249 {ECO:0000313|EMBL:EJP70619.1};
OS Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus)
OS (Tritirachium shiotae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX NCBI_TaxID=655819 {ECO:0000313|EMBL:EJP70619.1, ECO:0000313|Proteomes:UP000002762};
RN [1] {ECO:0000313|EMBL:EJP70619.1, ECO:0000313|Proteomes:UP000002762}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 2860 {ECO:0000313|EMBL:EJP70619.1,
RC ECO:0000313|Proteomes:UP000002762};
RX PubMed=22761991; DOI=10.1038/srep00483;
RA Xiao G., Ying S.H., Zheng P., Wang Z.L., Zhang S., Xie X.Q., Shang Y.,
RA St Leger R.J., Zhao G.P., Wang C., Feng M.G.;
RT "Genomic perspectives on the evolution of fungal entomopathogenicity in
RT Beauveria bassiana.";
RL Sci. Rep. 2:483-483(2012).
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
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DR EMBL; JH725150; EJP70619.1; -; Genomic_DNA.
DR RefSeq; XP_008593568.1; XM_008595346.1.
DR AlphaFoldDB; J4KRA6; -.
DR STRING; 655819.J4KRA6; -.
DR GeneID; 19883261; -.
DR HOGENOM; CLU_005688_2_0_1; -.
DR InParanoid; J4KRA6; -.
DR OrthoDB; 67337at2759; -.
DR Proteomes; UP000002762; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF46; GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002762};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 42..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 209..286
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 404..589
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 699..825
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
FT REGION 276..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..329
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 825 AA; 91332 MW; C52234459F6FFD82 CRC64;
MAAHAHHHYH AHAESTPLIH ASRNAALADQ RRRRENRTCR RFFLIAVSCI ALWGLFSFFF
HALFVWPYHY HRPHDGRHSA SDRDGGGVLT YDQLKAILLD TPNSEKAREW SKYYTAGAHL
AGKNFSQADW TRQKWESWGV SSSIAAYDVY INYPVDHSLS LLKKAKGHSG AWDVAFKASL
TEDILDEDPT SGSPDRIPTF HGYSASGNVT GQFVYVNYGT YADYEDLVRA GVDLRGKIAV
AKYGGIFRGL KIKRAQELGV IGVLIYSDPG DDGELTEENG YKAYPHGPAR QPSSVQRGSV
EFLSTRPGDP TTPGYPSKPG APRAPPNDVI PEIPSIPISY VDALPILRAL NGHGPNASDF
GNPWTRNLGL VHKGVKYNVG PSPAHLALNL YNEQEYVTTP QWDVIGIVNG TVPNEVIIIG
NHRDAWIVGG AGDPNSGSAI LNEVVRSVGV ALEAGWQPHR TIVFASWDGE EYGLIGSTEW
VEEYLPWIDD ANVAYINVDV GAAGPVFQAS AAPLLNQVLR DATRLVPSAN QTVPGQTIGD
VWDGRISTMG SGSDFTAFQD YAGVPCIDMG FKGGPRDPVY HYHSNYDSFA WMESFGDPGF
RYHRSMAQLL GLLVAELVDN LVIPFQAAEY ADALGTYLDQ VENKLRHYDY RDGDDNNHHA
AIDFASMDDE TLFLERGRVG SFQAKDDVVT VNADAFWTSL RDMRLSLARF RIVAGELDEQ
AEHAREALDR GLPWWNIVGK IRLGVTILLV NHKYKELERY FLFEGGLDGR SWFKHVVFAP
GLWTGYAGAV YPGLMESIDA KDYSNGLKWS GIINKCIRRA TKSLQ
//
