ID   J4KRI0_BEAB2            Unreviewed;       946 AA.
AC   J4KRI0;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   SubName: Full=Intracellular serine protease {ECO:0000313|EMBL:EJP70989.1};
GN   ORFNames=BBA_00619 {ECO:0000313|EMBL:EJP70989.1};
OS   Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus)
OS   (Tritirachium shiotae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX   NCBI_TaxID=655819 {ECO:0000313|EMBL:EJP70989.1, ECO:0000313|Proteomes:UP000002762};
RN   [1] {ECO:0000313|EMBL:EJP70989.1, ECO:0000313|Proteomes:UP000002762}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ARSEF 2860 {ECO:0000313|EMBL:EJP70989.1,
RC   ECO:0000313|Proteomes:UP000002762};
RX   PubMed=22761991; DOI=10.1038/srep00483;
RA   Xiao G., Ying S.H., Zheng P., Wang Z.L., Zhang S., Xie X.Q., Shang Y.,
RA   St Leger R.J., Zhao G.P., Wang C., Feng M.G.;
RT   "Genomic perspectives on the evolution of fungal entomopathogenicity in
RT   Beauveria bassiana.";
RL   Sci. Rep. 2:483-483(2012).
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC       ECO:0000256|RuleBase:RU003355}.
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DR   EMBL; JH725150; EJP70989.1; -; Genomic_DNA.
DR   RefSeq; XP_008593938.1; XM_008595716.1.
DR   AlphaFoldDB; J4KRI0; -.
DR   STRING; 655819.J4KRI0; -.
DR   GeneID; 19883631; -.
DR   HOGENOM; CLU_014118_0_0_1; -.
DR   InParanoid; J4KRI0; -.
DR   OrthoDB; 2247221at2759; -.
DR   Proteomes; UP000002762; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   PANTHER; PTHR43806:SF7; MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-1 PROTEASE; 1.
DR   PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000002762};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}.
FT   DOMAIN          646..875
FT                   /note="Peptidase S8/S53"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   ACT_SITE        652
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        694
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        858
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   946 AA;  105838 MW;  5DF714B6F1D6901D CRC64;
     MDPDDSRELW KTALGYLASK RPEKTSSPPS LRAERDSAWM RAHAYLRHEA VDEDGPSSSE
     DIERALGVLE NVIQYDFADD SDTNIPNAVP YPKLQTIRNM AKRPNRESHS TLNSTIRVSK
     RQRENEAVIQ ELSRWEADAK RRRVVTREEA SVVDDMEEPE VGFAILLRRH SESLHQGLRT
     QWSCVCQKCS GLSVGLALPL RRTSCKEETS FEMFFCVRSF SEITLQEARI TVKDVRSNKC
     MSTFEPGCNS LPEFAHICKS ITDSLSQSNR LHLLYDGDRF KRLRPEPKNF GGYQIPQAVS
     LSVFFQRQQE LRGGLSVLPL KAKRILAVIL ATALLPFLET PWVQPSFSHS NILFFQPLQY
     GELPSITKPF LDMEHVPLIS GNQADDGGAH ADPSISRHMV HPNASVLALG ILLCELHYCK
     PVNAWKNEEM GTGDVNSSYY ASIDILKSLE LDAGVDYYLA TKACLQWEYF PAGELTSFES
     VSVQKLFYQN VIKRLESELF KSWCLRSEDL SCLDARQGQQ YWGEIGQEIL RQQTTKFGSS
     AKSDQNFAVS SPPTSLHFTP PNPRAQMPLQ FPSHIPTNSQ VARPSTERLY LFDASHQKSS
     ENDTSLSDRW MDDLISSLHP HVDAFDATAH PPYVSSRKIA NAPTPVKIAI LDSGFDPENP
     LIRTDGHQLD PRIKDARNFV QGTGPYDYRD EIGHGTHALG VILNVAACAE IYIAKVANKE
     DLGRESYDAI TKARSPRCGA AIHHAVTEWD VDIISMSFGI REHNEPMTQA VALALHKQKL
     MFAAASNDGA NFGRAFPAKY TGVFCIHSTD GNGNPSAFNP TADEKDVNFS LLGEHVRSHW
     PAGRSGHHDS VKVLSGTSVA TPIAAGLAAM IMTFVRQQDH GSDAQSDRLG PWLKDAHAMD
     AVLKSMVRQR RGMGYDYITP HLLMDAQSSR ESIYNKIKDI KKHMYH
//