ID J4KSH4_9GAMM Unreviewed; 688 AA.
AC J4KSH4;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Ribonuclease G {ECO:0000256|ARBA:ARBA00017719};
GN ORFNames=NT02SARS_1040 {ECO:0000313|EMBL:EJP72709.1};
OS SAR86 cluster bacterium SAR86B.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; SAR86 cluster.
OX NCBI_TaxID=1123867 {ECO:0000313|EMBL:EJP72709.1, ECO:0000313|Proteomes:UP000010116};
RN [1] {ECO:0000313|EMBL:EJP72709.1, ECO:0000313|Proteomes:UP000010116}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22170421; DOI=10.1038/ismej.2011.189;
RA Dupont C.L., Rusch D.B., Yooseph S., Lombardo M.J., Richter R.A., Valas R.,
RA Novotny M., Yee-Greenbaum J., Selengut J.D., Haft D.H., Halpern A.L.,
RA Lasken R.S., Nealson K., Friedman R., Venter J.C.;
RT "Genomic insights to SAR86, an abundant and uncultivated marine bacterial
RT lineage.";
RL ISME J. 6:1186-1199(2012).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the RNase E/G family. RNase G subfamily.
CC {ECO:0000256|ARBA:ARBA00005663}.
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DR EMBL; JH611190; EJP72709.1; -; Genomic_DNA.
DR AlphaFoldDB; J4KSH4; -.
DR HOGENOM; CLU_003468_5_3_6; -.
DR Proteomes; UP000010116; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd04453; S1_RNase_E; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.1260.20; Ribonuclease E, catalytic domain; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR019307; RNA-bd_AU-1/RNase_E/G.
DR InterPro; IPR004659; RNase_E/G.
DR InterPro; IPR048583; RNase_E_G_thioredoxin-like.
DR InterPro; IPR003029; S1_domain.
DR NCBIfam; TIGR00757; RNaseEG; 1.
DR PANTHER; PTHR30001; RIBONUCLEASE; 1.
DR PANTHER; PTHR30001:SF1; RIBONUCLEASE E_G-LIKE PROTEIN, CHLOROPLASTIC; 1.
DR Pfam; PF10150; RNase_E_G; 1.
DR Pfam; PF20833; RNase_E_G_Thio; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000010116};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 39..114
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REGION 482..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..568
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 608..630
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..657
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..688
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 688 AA; 77644 MW; 997E6E173DEC7965 CRC64;
MKRILINSSY GDELRVALVD GAKLYDFDTE SPEINLLKGS IFKATVSRIE TSLDAAFVNF
GSERHGFLPL KDLSNEYFET HKGKKKCILE EGQEIVVQVT KEERGTKGAA LSTQIGLAGR
FLVLMPNSSR SGGISRRISG DERDEIKKSL DKLNIPESMS VIVRTNGLGR STEELSLDLN
YLLALWDEVC ISTPNAKAPS LIYKDDKLIV RVVRDYFKED IEEILVDDKD TYDEALKFMQ
AVIPDHAEKI KFYNEDIPLF NRYQIESQIE LAFQREISLN SGGSIVIDPT EAMTAIDVNS
ARSTKGKDIE ETAFKTNIEA AKEVARQLRL RDVGGLVVID FIDMLDESNQ NKVESAFRKA
VYSDRARVQV SSISRFGLLE VSRQRLRPSL NETYDIEHVL VRGPRSLGQS ILRIVSEDAA
KESTGEIQVY VPADVASYLL NEKRNDILSI EQLNKIRILV IADPYKSRPY YKVVRVKSSD
IKNTDSYNLT PPSPEPDINW RDNKNIKNTK PLVGSINPPK MPKKKQEGII SWIKSITGIE
TQEEEVKKKP KTKRRPRVNN KKTNNNAKKG FKKTVSKNPK AQNKSNKPNK NTLVKNNNTK
PKPKPKSKPK PKTEFNKKVI NDEKNTNKAV VESKSSKGAI KNTKPKSNNS DSINTKKKSP
GIIEIDKTKK EKKKPPTRAL NDPRNKNE
//
