ID J4TBU6_9FIRM Unreviewed; 391 AA.
AC J4TBU6;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=ribose-phosphate diphosphokinase {ECO:0000256|ARBA:ARBA00013247};
DE EC=2.7.6.1 {ECO:0000256|ARBA:ARBA00013247};
GN Name=prs_2 {ECO:0000313|EMBL:EJP19149.1};
GN ORFNames=HMPREF1140_2630 {ECO:0000313|EMBL:EJP19149.1};
OS Lachnoanaerobaculum sp. ICM7.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Lachnoanaerobaculum.
OX NCBI_TaxID=936594 {ECO:0000313|EMBL:EJP19149.1, ECO:0000313|Proteomes:UP000006599};
RN [1] {ECO:0000313|EMBL:EJP19149.1, ECO:0000313|Proteomes:UP000006599}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ICM7 {ECO:0000313|EMBL:EJP19149.1,
RC ECO:0000313|Proteomes:UP000006599};
RA Durkin A.S., McCorrison J., Torralba M., Gillis M., Methe B., Sutton G.,
RA Nelson K.E.;
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ribose-phosphate pyrophosphokinase family.
CC {ECO:0000256|RuleBase:RU004324}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJP19149.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ALJL01000032; EJP19149.1; -; Genomic_DNA.
DR RefSeq; WP_009663982.1; NZ_ALJL01000032.1.
DR AlphaFoldDB; J4TBU6; -.
DR PATRIC; fig|936594.3.peg.2218; -.
DR Proteomes; UP000006599; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0004749; F:ribose phosphate diphosphokinase activity; IEA:InterPro.
DR GO; GO:0009165; P:nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd06223; PRTases_typeI; 1.
DR Gene3D; 3.40.50.2020; -; 2.
DR InterPro; IPR029099; Pribosyltran_N.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR InterPro; IPR005946; Rib-P_diPkinase.
DR NCBIfam; TIGR01251; ribP_PPkin; 1.
DR PANTHER; PTHR10210:SF32; RIBOSE-PHOSPHATE DIPHOSPHOKINASE; 1.
DR PANTHER; PTHR10210; RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER; 1.
DR Pfam; PF00156; Pribosyltran; 1.
DR Pfam; PF13793; Pribosyltran_N; 1.
DR SUPFAM; SSF53271; PRTase-like; 2.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:EJP19149.1};
KW Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727,
KW ECO:0000256|RuleBase:RU004324}; Transferase {ECO:0000313|EMBL:EJP19149.1}.
FT DOMAIN 16..169
FT /note="Ribose-phosphate pyrophosphokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13793"
FT DOMAIN 215..311
FT /note="Phosphoribosyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00156"
SQ SEQUENCE 391 AA; 44527 MW; CB29B1778E46C6A5 CRC64;
MPNDFVFRDQ LPIAPLKIAA LESCYDFAKK VNDYIVEFRR NDTTELMNSK MDLHYRGYDC
DNYLLDIACP RFGSGEAKGI IKESVRGTDV FVMVDVLNHS LSYKLNGFTN YMSPDDHYQD
LKRIISASIA NAKRVNVIMP FLYESRQHKK TKRESLDCAL ALAELVDMGV SNIITFDAHD
PRVQNSIPLT GFDNFMPTYQ FVKALFTNVP DLKVNKDDMM IISPDEGAMN RAVYLANNLG
VDMGMFYKRR DYSKVIDGRN PIVAHEFLGS SVDGKDVIIM DDMISSGESM LDTAKELKKR
NAKRIIICAT FGLFTNGLDK FDEFHNLGLI DYVCTTNVHY RNPELLTKPW YLEADMTKYL
AAIINSYNHD VSIGKSLSPT MKIQNFVSKF K
//
