ID J4UKD4_BEAB2 Unreviewed; 1064 AA.
AC J4UKD4;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=DUF221 domain-containing protein {ECO:0000313|EMBL:EJP64632.1};
GN ORFNames=BBA_06626 {ECO:0000313|EMBL:EJP64632.1};
OS Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus)
OS (Tritirachium shiotae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX NCBI_TaxID=655819 {ECO:0000313|EMBL:EJP64632.1, ECO:0000313|Proteomes:UP000002762};
RN [1] {ECO:0000313|EMBL:EJP64632.1, ECO:0000313|Proteomes:UP000002762}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 2860 {ECO:0000313|EMBL:EJP64632.1,
RC ECO:0000313|Proteomes:UP000002762};
RX PubMed=22761991; DOI=10.1038/srep00483;
RA Xiao G., Ying S.H., Zheng P., Wang Z.L., Zhang S., Xie X.Q., Shang Y.,
RA St Leger R.J., Zhao G.P., Wang C., Feng M.G.;
RT "Genomic perspectives on the evolution of fungal entomopathogenicity in
RT Beauveria bassiana.";
RL Sci. Rep. 2:483-483(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; JH725168; EJP64632.1; -; Genomic_DNA.
DR RefSeq; XP_008599945.1; XM_008601723.1.
DR AlphaFoldDB; J4UKD4; -.
DR GeneID; 19889638; -.
DR HOGENOM; CLU_002458_2_1_1; -.
DR InParanoid; J4UKD4; -.
DR OrthoDB; 54187at2759; -.
DR Proteomes; UP000002762; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR022257; PHM7_ext.
DR PANTHER; PTHR13018:SF53; DOMAIN PROTEIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF12621; PHM7_ext; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 62..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 576..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 735..756
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 777..803
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 809..836
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 65..210
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 233..517
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 529..801
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT DOMAIN 968..1056
FT /note="10TM putative phosphate transporter extracellular
FT tail"
FT /evidence="ECO:0000259|Pfam:PF12621"
FT REGION 22..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 884..904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..392
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..902
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1064 AA; 120566 MW; F5C24BCE9552CD11 CRC64;
MDDPENWPWL VARLDLNQIH ATDAIPRSQN NDPRINSTRN DSNGQGTLSA TANSKSPSLS
KLGGTFIPIG IIFAVILILF VLLRPRLKRV YAPRTIHAIR RPLEPSPELP NGIFNWVVPF
FKISDTYILN NVTIDGFFFV RYLKVLRNIC FVGCLLAYPI LFPINATGGN GNSQLSLLTI
GNVKDSNKLY AHLFVAWAFF GFVLFTIVRE CIYYVNLRQA YLSSPHYAQR ISSRTMLITG
LPEKYQDEAR LRKLYGDSAK RIYLPRSSKV LAKLVKEREQ TAKRLEDAEV KLIKMTNHAR
NQYLKKHPDH PVSQPPPERI QEQREMDLES ASSERELAAA SPKLSRFSSE KLEVDLPGPR
LLSDESIDNL QQRDSDETKV DEKVDDTEKK EDHVEIEEDL DYVHPYGLHD TLPDLRGSVA
SLWIPTKKRP HHRPIGNFLR RVDTIRWTRN RLRELNLLIF KTRRVVRRGE AGTVSAAFIE
FDSQESAQAA QQVLAHHRPL QMSARLLGIR PDEVIWSSLR MKWWELIMRR TAILALVLAA
IVFWSIPAAF VGLVSNVDSL IKIVPFLSWI NLLPKLIVGF IQGFMPALAL TLLMAAVPFM
LRLCGRVSGL SSMHQVELFT QNAYFAFQVV QVFLITTLTS AASSAITDII KNPLGAKDLL
AKSLPSASDF YLSYILIQCV LSGCKDLLQI WPFIRHVVLA KITDNPRTRF KAWKELTTPG
WGGIFPVYSN MGVIALSYSC ISPLVLVFAA FGLWFIQIVW KYKLIYVMDS THDSKGLFYP
QALLHLIVGL YLAEICMIGL FALNSSFPPV VLMLIFLLFT LLVHMSISDA IAPLLVSLPQ
TMKIEEEIQI EEKQKAEAAA IAAEESSDTP TGAANSYYDE TQTFGEERIE SEEEEEEEEE
GEQHVVTGTR AMEGASSVRS TAMEFFKGSI NKKVKTELES PFLKHWLGKI GINIGPENAG
KPSFFQRFLH PEEYEDFIAL RKLIPADSLP NKVYAENCSY TPPDMWMPKP SLWIPRDEAR
VSRQEVAHTR VYTPISDRGA ELDKDGRVIV YFEQAPCDEP RLLM
//
