ID J4VYS0_9FIRM Unreviewed; 394 AA.
AC J4VYS0;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Thiazole biosynthesis protein ThiH {ECO:0000313|EMBL:EJU19366.1};
GN Name=thiH {ECO:0000313|EMBL:EJU19366.1};
GN ORFNames=HMPREF1152_0436 {ECO:0000313|EMBL:EJU19366.1};
OS Mogibacterium sp. CM50.
OC Bacteria; Bacillota; Clostridia; Eubacteriales;
OC Eubacteriales Family XIII. Incertae Sedis; Mogibacterium.
OX NCBI_TaxID=936375 {ECO:0000313|EMBL:EJU19366.1, ECO:0000313|Proteomes:UP000003142};
RN [1] {ECO:0000313|EMBL:EJU19366.1, ECO:0000313|Proteomes:UP000003142}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM50 {ECO:0000313|EMBL:EJU19366.1,
RC ECO:0000313|Proteomes:UP000003142};
RA Durkin A.S., McCorrison J., Torralba M., Gillis M., Methe B., Sutton G.,
RA Nelson K.E.;
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJU19366.1}.
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DR EMBL; ALNL01000044; EJU19366.1; -; Genomic_DNA.
DR RefSeq; WP_009644839.1; NZ_ALNL01000044.1.
DR AlphaFoldDB; J4VYS0; -.
DR STRING; 936375.HMPREF1152_0436; -.
DR PATRIC; fig|936375.3.peg.1718; -.
DR eggNOG; COG0502; Bacteria.
DR OrthoDB; 9801120at2; -.
DR Proteomes; UP000003142; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR010722; BATS_dom.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR012726; ThiH.
DR InterPro; IPR034428; ThiH/NoCL/HydG-like.
DR NCBIfam; TIGR02351; thiH; 1.
DR PANTHER; PTHR43583; 2-IMINOACETATE SYNTHASE; 1.
DR PANTHER; PTHR43583:SF1; 2-IMINOACETATE SYNTHASE; 1.
DR Pfam; PF06968; BATS; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00301; 2-iminoacetate_synthase_(ThiH); 1.
DR SFLD; SFLDG01060; BATS_domain_containing; 1.
DR SMART; SM00876; BATS; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000003142};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 273..386
FT /note="Biotin and thiamin synthesis-associated"
FT /evidence="ECO:0000259|SMART:SM00876"
SQ SEQUENCE 394 AA; 44401 MW; E3E1A6F6CDC010D7 CRC64;
MNGKARIDHM KYLEGMEIIS HEIYDAVLKE MNGYRPEHYG DSDVMRALEH ESCSVDDFKV
LLSPAAGKYL EQLAKRAKLE KDKHFGNSVN MFTPLYISNY CENYCIYCGF NCHNRIHRAK
LNGAEIEREM QAIAATGLEE ILILTGESRS MSDVNYIGEA CKIGRKYFKN VGVEIYPINS
DEYAFLHSCG ADYVTVFQET YDSDEYEKLH LSGHKRIFPY RFNAQERALI GGMRGVGFAA
LLGLGDFRRD ALATGLHAYM LQRKYPWAEI SFSCPRLRPI ISNSDDDMSF SLSSDSETVG
ERQLLQAMCA YRIFMPFAAM TLSTRERTGF RDHAVAIAAT RISAGVDTGI GSHSDDTATG
DNQFEIADGR TVDEIYSALC SHGMQPVMND YVYV
//
