ID   J4WHC2_9FIRM            Unreviewed;      1038 AA.
AC   J4WHC2;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Diguanylate cyclase (GGDEF) domain protein {ECO:0000313|EMBL:EJU24551.1};
GN   ORFNames=HMPREF1143_1332 {ECO:0000313|EMBL:EJU24551.1};
OS   Peptoanaerobacter stomatis.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Peptoanaerobacter.
OX   NCBI_TaxID=796937 {ECO:0000313|EMBL:EJU24551.1, ECO:0000313|Proteomes:UP000005244};
RN   [1] {ECO:0000313|EMBL:EJU24551.1, ECO:0000313|Proteomes:UP000005244}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OBRC8 {ECO:0000313|EMBL:EJU24551.1,
RC   ECO:0000313|Proteomes:UP000005244};
RA   Durkin A.S., McCorrison J., Torralba M., Gillis M., Methe B., Sutton G.,
RA   Nelson K.E.;
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJU24551.1}.
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DR   EMBL; ALNK01000005; EJU24551.1; -; Genomic_DNA.
DR   AlphaFoldDB; J4WHC2; -.
DR   PATRIC; fig|796941.3.peg.286; -.
DR   Proteomes; UP000005244; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   PANTHER; PTHR33121:SF78; CYCLIC DI-GMP PHOSPHODIESTERASE PDEI-RELATED; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005244};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          632..767
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          776..1025
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
SQ   SEQUENCE   1038 AA;  120245 MW;  932EF51B9A4F1168 CRC64;
     MFKMNKKDIT FKNRHSITSI MVLSFLGVLL IQLVVLFFNF ILLRTDHKLE QNTYRYIFEK
     VESRSRELER YLTELWANSE YMKQIMDFSQ TVYNEHVNLG KNFVINKDIS GSLLDMVELM
     EISGAFIVFD DKPDMLGIKK AVHLADANLR TKFADKSDII LRVGEEKIAG DLGVYLENDW
     KPFIDTRTMS KTIYEKAIKI AKTVNPREKT GFWFSPSDVS DTNGRSIYFI QPLFDDSTGI
     FYGVIGIEVG DELINEILRY TELSESGKGA YILANEKYVS AVNTNYDVIS IQGPYVKRLV
     KDNELFAHKI KNKYYNEAYK IQDNKYLTVL DFENTNKDMT LIAIQRPIRL SAKDSSENID
     TNWYLMGVID KSELEIYSKE LIESIIETLL LSLIIDGIII YLVSYLIGYP LRKLSNDIKE
     SYTKGGLRKI KHMNIVEIDN IIDTIEVLSQ RLLSSSKKFQ GILDSASIPI IAAEKDEASG
     VVYKMGELSS IFPGYINNEK FEVRMSAEEY DKASRYFFSD TIIIDSIYDI EKDTQIDIRK
     KIWNGESYYI KVITRQVKNY WRTYEDMSDD SNETSDKKTV TLQVIMDYTK DMIEKIKIQK
     ERDFDVLTDL LNRLSFKERV EEYIEKDVRK SKKAAMVMWD LDNLKYVNDT YGHDFGDSYI
     RCAGSIIGIL QGKDSFVARV SGDEFFAFIE YEYDKDEIRQ KIENIKIKLD STNLRVSEDI
     SVRVRATSGI AWYPDDATVY DDLHRLVDFA MYTAKNSQKG SIGEFNRDSY DKNYILISGR
     EDLNKFIDEK QVKFAFQPIV SAKDGEVFAY EALMRSVSDK IKNVGDIMRL AKSQSKLLDI
     EILTFEGVLR TVSKYTEKFK DKHIFINSIA STSIPEHRFY ELLNNYKDII DYSKMVVEII
     ESEEVDLDSL SIKQRLATEI NAQIAIDDFG SGYATESWLL QVNPNFVKID MALIRDIDKD
     MERQSIVENI LKYTKERKIK VICEGVETHQ EMKKLINMGA DFIQGFYLAK PDFEIKDISR
     EKKREIQVLN VLKGGQSF
//