ID J4X6D8_9GAMM Unreviewed; 478 AA.
AC J4X6D8;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=isochorismate synthase {ECO:0000256|ARBA:ARBA00012824};
DE EC=5.4.4.2 {ECO:0000256|ARBA:ARBA00012824};
DE AltName: Full=Isochorismate mutase {ECO:0000256|ARBA:ARBA00041564};
GN ORFNames=NT02SARS_1722 {ECO:0000313|EMBL:EJP74130.1};
OS SAR86 cluster bacterium SAR86B.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; SAR86 cluster.
OX NCBI_TaxID=1123867 {ECO:0000313|EMBL:EJP74130.1, ECO:0000313|Proteomes:UP000010116};
RN [1] {ECO:0000313|EMBL:EJP74130.1, ECO:0000313|Proteomes:UP000010116}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22170421; DOI=10.1038/ismej.2011.189;
RA Dupont C.L., Rusch D.B., Yooseph S., Lombardo M.J., Richter R.A., Valas R.,
RA Novotny M., Yee-Greenbaum J., Selengut J.D., Haft D.H., Halpern A.L.,
RA Lasken R.S., Nealson K., Friedman R., Venter J.C.;
RT "Genomic insights to SAR86, an abundant and uncultivated marine bacterial
RT lineage.";
RL ISME J. 6:1186-1199(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chorismate = isochorismate; Xref=Rhea:RHEA:18985,
CC ChEBI:CHEBI:29748, ChEBI:CHEBI:29780; EC=5.4.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000799};
CC -!- SIMILARITY: Belongs to the isochorismate synthase family.
CC {ECO:0000256|ARBA:ARBA00005297}.
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DR EMBL; JH611160; EJP74130.1; -; Genomic_DNA.
DR AlphaFoldDB; J4X6D8; -.
DR HOGENOM; CLU_006493_8_4_6; -.
DR Proteomes; UP000010116; Unassembled WGS sequence.
DR GO; GO:0008909; F:isochorismate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR015890; Chorismate_C.
DR InterPro; IPR004561; IsoChor_synthase.
DR NCBIfam; TIGR00543; isochor_syn; 1.
DR PANTHER; PTHR42839; ISOCHORISMATE SYNTHASE ENTC; 1.
DR PANTHER; PTHR42839:SF2; ISOCHORISMATE SYNTHASE ENTC; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000010116}.
FT DOMAIN 211..463
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
SQ SEQUENCE 478 AA; 53430 MW; 78D098F0E32BE7E0 CRC64;
MSLPLPILPP SYCDEQTDLH PYLDDLISRS KTYNQSHFLS VTIETDYSDP LAILEEIHTE
ETPICYLEKP SKEFSIAAGE YLIVNRFSGE DRFLKGKEWA ENIFQKIQVA GDHRVAGTGP
TLFLSATFEN EPSDSEQIPP LEIFLPRWQV VRKEGSNFII LNFEICPNSS TKNIIAEFND
QISKIRGLRY NNKNALDPKL INVGNPKENY DYEEAVEKAL DEIKKQKLSK IVLSRQLSFQ
TDSQLPAFSI AHALREKFSD CHTFCISQPN HGLMVGATPE RLLRTSGNSF ETEALAGSAP
RGVSAGKDAH WGKTLLGRDK EILEHKLVIQ SILRRLSSIG INNCEEGKSR ILRLANLQHA
KTPLRAYPVT GIHPFEVLSA LHPTPAMGGS PRDIALPLVK KLEKAPRGWY SGVMGWIDNR
GRGEFVVPIR CGKISSKKLT LYAGAGLVDG SIAKQEKKET DWKLQAMLEV ITGRTNLP
//
