ID   J4XLS0_9ACTN            Unreviewed;       491 AA.
AC   J4XLS0;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   SubName: Full=Histidine--tRNA ligase {ECO:0000313|EMBL:EJU35316.1};
GN   ORFNames=HMPREF1155_0687 {ECO:0000313|EMBL:EJU35316.1};
OS   Slackia sp. CM382.
OC   Bacteria; Actinomycetota; Coriobacteriia; Eggerthellales; Eggerthellaceae;
OC   Slackia.
OX   NCBI_TaxID=1111137 {ECO:0000313|EMBL:EJU35316.1, ECO:0000313|Proteomes:UP000004399};
RN   [1] {ECO:0000313|EMBL:EJU35316.1, ECO:0000313|Proteomes:UP000004399}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM382 {ECO:0000313|EMBL:EJU35316.1,
RC   ECO:0000313|Proteomes:UP000004399};
RA   Durkin A.S., McCorrison J., Torralba M., Gillis M., Methe B., Sutton G.,
RA   Nelson K.E.;
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJU35316.1}.
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DR   EMBL; ALNO01000001; EJU35316.1; -; Genomic_DNA.
DR   AlphaFoldDB; J4XLS0; -.
DR   PATRIC; fig|1111137.3.peg.208; -.
DR   Proteomes; UP000004399; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR041715; HisRS-like_core.
DR   InterPro; IPR004516; HisRS/HisZ.
DR   PANTHER; PTHR43707:SF1; HISTIDINE--TRNA LIGASE, MITOCHONDRIAL-RELATED; 1.
DR   PANTHER; PTHR43707; HISTIDYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF13393; tRNA-synt_His; 2.
DR   PIRSF; PIRSF001549; His-tRNA_synth; 2.
DR   SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000313|EMBL:EJU35316.1}.
FT   DOMAIN          88..321
FT                   /note="Class II Histidinyl-tRNA synthetase (HisRS)-like
FT                   catalytic core"
FT                   /evidence="ECO:0000259|Pfam:PF13393"
FT   DOMAIN          421..481
FT                   /note="Class II Histidinyl-tRNA synthetase (HisRS)-like
FT                   catalytic core"
FT                   /evidence="ECO:0000259|Pfam:PF13393"
FT   REGION          1..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          353..390
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        363..390
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   491 AA;  51392 MW;  1CD2113A9E2E228D CRC64;
     MVSSENQAMT LPAGQAMVPS TDRATAPSTD QTAPSAGRAA DAPTDRTADP RAGRATAPRA
     GKPGYPSSDR TPGRAGLIPE AFSSDDLEWD TRVTLALDAL YRTSGYERYR MNKFEPYDLY
     LEHRGFLRDD AVISFTDPRG RLMALKPDVT MSIVKNASAD AAVERLFYIE NVFRVPPGGS
     EFAEIAQMGL ECLGCDSGYV QSDVDAEVVA LACRTLDVCG GRSRLAVSHM GLLSALLDAC
     LLEDEPREQA LRCIRLKNAA GLADVLHGAG APSESQDALL GALAVSLPLS SAVESLKALP
     LSRVALEAIE ALEALVKRLV ASGEEPCAIE AEPDAAGNTD EVGEELCAIG KESGAARAEP
     DAAGRPDAIE ADPDATRKPD TAGEEPCAMR KEPDAFPVAA GAAAGGRGVS EGKPPAPRLE
     ADRLFFDLSL VGEAGYYTGL AFQGYIEGLP RAVLAGGRYD GLMEKVGRSQ GAAGFALYLG
     EIAPAFTGGR A
//