ID J4XRF5_9FIRM Unreviewed; 591 AA.
AC J4XRF5;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00015486};
DE EC=2.4.2.21 {ECO:0000256|ARBA:ARBA00011991};
DE AltName: Full=N(1)-alpha-phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00030686};
GN Name=cobT {ECO:0000313|EMBL:EJO22961.1};
GN ORFNames=HMPREF1148_1052 {ECO:0000313|EMBL:EJO22961.1};
OS Selenomonas sp. FOBRC6.
OC Bacteria; Bacillota; Negativicutes; Selenomonadales; Selenomonadaceae;
OC Selenomonas.
OX NCBI_TaxID=936572 {ECO:0000313|EMBL:EJO22961.1, ECO:0000313|Proteomes:UP000006984};
RN [1] {ECO:0000313|EMBL:EJO22961.1, ECO:0000313|Proteomes:UP000006984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FOBRC6 {ECO:0000313|EMBL:EJO22961.1,
RC ECO:0000313|Proteomes:UP000006984};
RA Durkin A.S., McCorrison J., Torralba M., Gillis M., Methe B., Sutton G.,
RA Nelson K.E.;
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide =
CC alpha-ribazole 5'-phosphate + H(+) + nicotinate;
CC Xref=Rhea:RHEA:11196, ChEBI:CHEBI:15378, ChEBI:CHEBI:15890,
CC ChEBI:CHEBI:32544, ChEBI:CHEBI:57502, ChEBI:CHEBI:57918; EC=2.4.2.21;
CC Evidence={ECO:0000256|ARBA:ARBA00001058};
CC -!- PATHWAY: Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-
CC ribazole from 5,6-dimethylbenzimidazole: step 1/2.
CC {ECO:0000256|ARBA:ARBA00005049}.
CC -!- SIMILARITY: Belongs to the CobT family.
CC {ECO:0000256|ARBA:ARBA00007110}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJO22961.1}.
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DR EMBL; ALKG01000064; EJO22961.1; -; Genomic_DNA.
DR RefSeq; WP_009655830.1; NZ_ALKG01000064.1.
DR AlphaFoldDB; J4XRF5; -.
DR STRING; 936572.HMPREF1148_1052; -.
DR PATRIC; fig|936572.3.peg.857; -.
DR eggNOG; COG2038; Bacteria.
DR UniPathway; UPA00061; UER00516.
DR Proteomes; UP000006984; Unassembled WGS sequence.
DR GO; GO:0008939; F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd02439; DMB-PRT_CobT; 1.
DR Gene3D; 1.10.1610.10; -; 3.
DR Gene3D; 3.40.50.10210; -; 1.
DR InterPro; IPR003200; Nict_dMeBzImd_PRibTrfase.
DR InterPro; IPR023195; Nict_dMeBzImd_PRibTrfase_N.
DR InterPro; IPR036087; Nict_dMeBzImd_PRibTrfase_sf.
DR PANTHER; PTHR43463; NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR43463:SF1; NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE; 1.
DR Pfam; PF02277; DBI_PRT; 2.
DR SUPFAM; SSF52733; Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT); 2.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000313|EMBL:EJO22961.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EJO22961.1}.
SQ SEQUENCE 591 AA; 61810 MW; 2414DAFA384693D9 CRC64;
MNLLEQTIAT IHVPDTELSS AVDAALSAQT SRDFGHLRSI LLRYMNITGE RHPAPPQTSV
IISCADHGVA AESVSAYPPE TTLNMMCNYL IARGGAANAA ANYAGARLVV ADLGVNAAYD
DIPGLLQHSI ARGTANMTKG SAMTRAQAIA AIETGIALAN DCADRGDRCI LPGEMGISNT
TSSAAIVAAF LGLTPEEVTG RGANISDARL AHKIEIVRRA LSVNRPDPHD GLDVLAKVGG
FELGCIAGII LGAAARHMLV ILDGANTTSA ALIAHALAPD CAHYLLASHA SLTEHSHPHA
LRRLGLTPIL RLDIRLSEAA GSSIALRLLE RMLKIWEAVD APSHNAMPPP WDTGEGDCAA
VEGAPLSISP LHQSSMDACQ YRLDNLAKPI HSLGYLERIA VQLAGILGTE RPPIDTKVAL
LLITDGELPA DLTCILNALT TSASIPVHIL TVSQVIKDTR TAYETAYALA RTYPILILGA
YEREESAAVS AALTGSLHGA AAGASLILPG DARTDRAAHT AADENTALRP YILHILPDML
MIDTELTAGI AGILGIDIVR AALHVVNDMK TFTETGVAVA IDGAGAGRQV R
//
