ID J5GN17_9FIRM Unreviewed; 749 AA.
AC J5GN17;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=DNA internalization competence protein ComEC/Rec2-like protein {ECO:0000313|EMBL:EJP19858.1};
GN ORFNames=HMPREF1140_2366 {ECO:0000313|EMBL:EJP19858.1};
OS Lachnoanaerobaculum sp. ICM7.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Lachnoanaerobaculum.
OX NCBI_TaxID=936594 {ECO:0000313|EMBL:EJP19858.1, ECO:0000313|Proteomes:UP000006599};
RN [1] {ECO:0000313|EMBL:EJP19858.1, ECO:0000313|Proteomes:UP000006599}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ICM7 {ECO:0000313|EMBL:EJP19858.1,
RC ECO:0000313|Proteomes:UP000006599};
RA Durkin A.S., McCorrison J., Torralba M., Gillis M., Methe B., Sutton G.,
RA Nelson K.E.;
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJP19858.1}.
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DR EMBL; ALJL01000027; EJP19858.1; -; Genomic_DNA.
DR RefSeq; WP_009663600.1; NZ_ALJL01000027.1.
DR AlphaFoldDB; J5GN17; -.
DR PATRIC; fig|936594.3.peg.1839; -.
DR Proteomes; UP000006599; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 51..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..169
FT /note="DUF4131"
FT /evidence="ECO:0000259|Pfam:PF13567"
FT DOMAIN 209..479
FT /note="ComEC/Rec2-related protein"
FT /evidence="ECO:0000259|Pfam:PF03772"
FT DOMAIN 515..712
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF00753"
SQ SEQUENCE 749 AA; 85219 MW; 0B812E2C8AA3FCE8 CRC64;
MKRPCVLIVT ACLLGELLGY YFGIYRLAVG IPIAAAVLII LKFKKIIKFK LIYFLIFFLI
CSIFILRIKY EIRYMNNFIA DVDNDGKNTS LCGRVKSIIF KDDNVMIICE GVIYYLKDEI
FLNDIHIGNK VKFEGRLEEI SKGTNPGEFD AKSYYRTKGI YVKMSVSDYR VVDKSCDNIG
EFFFSLRQYL NTKIDETFES DKAGFIKAII LGMRGELDKG TYKLYQRSGI SHILAISGLH
VSLFGIGLYK LLRKILQRSF LLSASLASVF LVFYGLLVGD SVSIVRASTM LILYFIAEVI
GRSYCIISAL SISAVTISLI SPFEPFGLSF QLSFAAVLSL GGPIAFIIKR FKPVEKKDKS
SCSYRVFKIL VVSIGVQLLT LPVTLYYFYT FPLYAFLINI LVIPLMSFVL YSSMLSLVLN
ILRLILYKYI SVFTVAILRF YDFLCIITKY LPYHYIVFGR PKPWQIFIYY ILLLLIIAIS
VLRCRKIYLL LSLFTVLILY PFLKTESVVY LDVGQGDGIY MHIDDLDILI DGGSTSKPSL
GEYSMEPFLL YKGVDDIEMS FITHSDIDHI SGILYLLDTD IKIENMFLPY QAMKDNSYDK
LKEKALKAGC NIRYLSMGDC FERKNLKIDC LWPDTSDKEN VNEQSQTFVI ETYGKRLLFT
GDIGKSSEES ILNYFDIGKV DILKVAHHGS KNSSLKAFIE NVSPEYAVIS CGKNNHYGHP
SPETIETLKE NGCIIFETSK MGAIEVKLR
//
