ID J5JVE0_BEAB2 Unreviewed; 1142 AA.
AC J5JVE0;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=DNA (cytosine-5-)-methyltransferase {ECO:0000256|ARBA:ARBA00011975};
DE EC=2.1.1.37 {ECO:0000256|ARBA:ARBA00011975};
GN ORFNames=BBA_04899 {ECO:0000313|EMBL:EJP66406.1};
OS Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus)
OS (Tritirachium shiotae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX NCBI_TaxID=655819 {ECO:0000313|EMBL:EJP66406.1, ECO:0000313|Proteomes:UP000002762};
RN [1] {ECO:0000313|EMBL:EJP66406.1, ECO:0000313|Proteomes:UP000002762}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 2860 {ECO:0000313|EMBL:EJP66406.1,
RC ECO:0000313|Proteomes:UP000002762};
RX PubMed=22761991; DOI=10.1038/srep00483;
RA Xiao G., Ying S.H., Zheng P., Wang Z.L., Zhang S., Xie X.Q., Shang Y.,
RA St Leger R.J., Zhao G.P., Wang C., Feng M.G.;
RT "Genomic perspectives on the evolution of fungal entomopathogenicity in
RT Beauveria bassiana.";
RL Sci. Rep. 2:483-483(2012).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016}.
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DR EMBL; JH725160; EJP66406.1; -; Genomic_DNA.
DR RefSeq; XP_008598218.1; XM_008599996.1.
DR AlphaFoldDB; J5JVE0; -.
DR STRING; 655819.J5JVE0; -.
DR GeneID; 19887911; -.
DR HOGENOM; CLU_003836_2_0_1; -.
DR InParanoid; J5JVE0; -.
DR OrthoDB; 317994at2759; -.
DR Proteomes; UP000002762; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 2.30.30.490; -; 2.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR018117; C5_DNA_meth_AS.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10629:SF54; DNA METHYLTRANSFERASE DIM-2; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR PRINTS; PR00105; C5METTRFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51038; BAH; 1.
DR PROSITE; PS00094; C5_MTASE_1; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002762};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}.
FT DOMAIN 407..524
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT REGION 661..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1115..1142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1115..1131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 768
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 1142 AA; 128283 MW; C9A104A1163C14A4 CRC64;
MKLTADLDLD LDLNLDLDLD LDLDAISSEQ HDTRILATTC LPGVLSGIDY DGSYSSHGSK
DDDLEEDGPT GSYPISVHIP ECMLISPRSC YTPFDPPCPV ASERDALRIL LPQRYAKNGF
LELKLDDFAV YCDTKFRPEE MRSLSQLGTE PHSTPLFFDG MLSHGTQSLY VRRVRIHALP
IGNYGQESRH QTRDNIWIQS EENATSDVFY KLGSPAPEYK RFFELFVWVA DLAKYFVDFL
TVMRAIERPV TIHHFRRDFA AWLLALYAKS DKIEAVKTWM CKHPRQDYRS AVNANVDFLH
KESVGVLGER RAYFHDLWNE VFFFQTYTPY IAHNEDKCTI VTKYIYDCFH HLPFGKRLKV
VDLSAHTKRL RLEVIAQRPM LPINGTQVTP AGHGKIGPGD TISTARDTVD SGTDWEKEEA
KGDEYSDLWF ALVQSVSVNS DGVRVFEVIW YYRPVDTLCG LMQYPWSDEL FLSDHCSCEE
GTKIREDEVR SVHEVDFGGT PETTKEFFCR QSYLSDDKIW VTLTQSHLTC RHNNDAPIPD
SAEEYCLGDT VLVKSGRNSN VCHPCEIIET KQENGRLRFV FRKLPIRHAV DLTARNAPPN
EVVYTDEIVK SGPSSIVSRC HVRWFPQTRP VPTPYDRDGV GAFFFLTHQK KWTGNGYITS
PLEEAPPSLN QGHDPQQDSK PKLRGLDLFC GGGNFGRGLE EGGSVTMKWA NDVNSKALHT
YMANTEPGQI YPFLGSIDDF QRLAFQGRFA DNIPQVGEVD FISGGSPCPG FSQLTNDKET
DAQRKNQSLV AAFASCVDLY RPKYGILENV AGIIQKHQNR GHDVFSQLMC ALVGMGYQAR
LVLLDALSCG SAQVRSRVFI IFAAPGWTLP EAPIQTHSHQ PNVKNFKLGR LPTGEPMARR
EVASCTPFSY KSASQAAAGL PSLYDATPDI CIAFPDHRVV SHTNTNTMRN RIRLIPKAPY
GMNFSQAWYG RLGTRPRVAG RGVLTRSERN MFSLRGEATM STSIQSRAYG RQPPNQPMAT
IVTRASPRDA KQGRTIHWSE DRCLSVMEAK RGQGFLDEEL LLGSADVQYR IIGNSVAREV
SLALGVVFAE AVMRSYGQGV EDLAVDSEDE VTIKTEMSVP TTPGATRQQG ENNGRNKRRR
VG
//
