ID   J5JYU3_BEAB2            Unreviewed;      1652 AA.
AC   J5JYU3;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   SubName: Full=GTPase-activator protein for Ras-like GTPase {ECO:0000313|EMBL:EJP69593.1};
GN   ORFNames=BBA_01558 {ECO:0000313|EMBL:EJP69593.1};
OS   Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus)
OS   (Tritirachium shiotae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX   NCBI_TaxID=655819 {ECO:0000313|EMBL:EJP69593.1, ECO:0000313|Proteomes:UP000002762};
RN   [1] {ECO:0000313|EMBL:EJP69593.1, ECO:0000313|Proteomes:UP000002762}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ARSEF 2860 {ECO:0000313|EMBL:EJP69593.1,
RC   ECO:0000313|Proteomes:UP000002762};
RX   PubMed=22761991; DOI=10.1038/srep00483;
RA   Xiao G., Ying S.H., Zheng P., Wang Z.L., Zhang S., Xie X.Q., Shang Y.,
RA   St Leger R.J., Zhao G.P., Wang C., Feng M.G.;
RT   "Genomic perspectives on the evolution of fungal entomopathogenicity in
RT   Beauveria bassiana.";
RL   Sci. Rep. 2:483-483(2012).
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DR   EMBL; JH725152; EJP69593.1; -; Genomic_DNA.
DR   RefSeq; XP_008594877.1; XM_008596655.1.
DR   STRING; 655819.J5JYU3; -.
DR   GeneID; 19884570; -.
DR   HOGENOM; CLU_000972_1_1_1; -.
DR   InParanoid; J5JYU3; -.
DR   OrthoDB; 12619at2759; -.
DR   Proteomes; UP000002762; Unassembled WGS sequence.
DR   GO; GO:0015629; C:actin cytoskeleton; IEA:UniProt.
DR   GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR   CDD; cd21206; CH_IQGAP; 1.
DR   CDD; cd05127; RasGAP_IQGAP_like; 1.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR000593; RasGAP_C.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR14149:SF14; PATTERNED EXPRESSION SITE; 1.
DR   PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR   Pfam; PF00307; CH; 1.
DR   Pfam; PF00612; IQ; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   Pfam; PF03836; RasGAP_C; 1.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM00015; IQ; 6.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF143885; RGC domain-like; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS50096; IQ; 9.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002762}.
FT   DOMAIN          270..376
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          1019..1235
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   REGION          1..158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          436..463
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        14..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..104
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..158
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1652 AA;  188871 MW;  03BAAB238D7AA80D CRC64;
     MFRPHPLRQS HTLEVVPPDN NISRQLSTTS SSASSGYSYA SDQTQNTQYS SLSSGFSPPK
     PTPTAYTHRR GQSDVIARAR LFESGDMNSP SRDAASTRPS LRQLPQGPVA SPPRPSASPE
     QKLRHLRGQS VDISKLSISQ NDGPASPASP PRLSSMRPNS MLLTRSDSML RGAGAVPSNS
     PHICAPELEK LGRSSTTQLR TLSKLAQSNT TDDFSITSPT QEVVGLRGRR RLQRAEQSAA
     GKTTKSNAYG WEGRNWMDKQ RQFLQAYEYL CHIGEAREWI EDITNKTLPP IVELEEALRD
     GVTLAEVVEA LNPDRHFRIF RHPKLQYRHS DNIAIFFRYL DEVEVPDLFR FELIDLYEKK
     NIPKVIYCIH ALSWLLFRKG IVDFRIGNLV GQLEFEHHEL EAMQKGLDKL GVSMPSFGNM
     GADFGVPEPE PQETEEERID RELAQETAQI TDLQAQIRGA LARLRLGNDM QDLWDGEGAL
     IDLQSRIRGE FTRQIMGYRL QMRRSSIKVQ SAARGFLTRR RMKNDGRCWK AIEPDILTLQ
     SMIRANKVRK EVRDITSMVS QSEGAVREIQ AISRGFFIRK DLIVQKRETK QASGDVLNLQ
     ALARGALRRG QLNTQRNLLD GFNGATVQLQ AAARAALTRF QISRERDALQ SFASSLTMLQ
     SLVRGKAARA QHIGTQMEVK KHSLDIGRFQ AAIRAAAVRR DIASQLDSLH LNEPDTIELQ
     SRIRGMFERR SVSALQQKLD RVTPTVTSLQ SRIRGFNYRR QHEALMTELV SHNAETAAFQ
     AMLKAMMERA RVDDLLTELY EEEESIVELQ SAARAFLVRA RFEEKKRFFD ENMQKVIKIQ
     SFVRAKVQGE AYKSLTTGKN PPVNAVKNFV HLLNDSDFDF NEEVEFERMR KTVVQQVRQN
     EMLEQYIDQL DIKIALLVKN KITLDEVVSH QHNYGGGSSM GMLANSSISS SNQFDLKALN
     KGSRKKLESY QQLFFCLQTQ PQYLARLFKH LREQGTPDSE SKRIELLIMA MFGYAQKRRE
     EYYLLKLIAR SIREEIEGNR SLQEYCRGTF FWSKLLANYT RSPRDRKFLR GLLGPLIRDN
     IVEDPALDLE SDPMQIYRAS INNEELRTGR PDGRPLDVPR EVAIRDPETR RLFIDHLRDL
     REICDQLFLA MEDHVFKTPY GLRFLCRQMF ESLRQHFNRD SPDILLQHVT SWYWKFYLQP
     AIVSPENVGV IEKTLSPLQK RNLGEVAKVL SQIASGRPFG GENVYLQPLN AFVAESIERL
     RHIMSELISV PDAESTFDID EFNDLYAKNK PTLYIKMADV FSIHNLIVSQ LPFLCPTRDD
     VLREIIQDLG SAKTNESEMS AAGSSDIQMF LTPRLHNVED PDAEVKALFM ETKRCVLYII
     RVQTGNNLLE ILVKPITEED DAKWASLLQG DFAPSGSHGA YSEANMIDVT RMSYYELKRT
     ALENVMRLEQ MGRISKHNNY QDILNAIASD IRSKSRRRVQ RQRELEGVNL TLGNLHEKAN
     YLEQQRKSYD DYIEQAMMTL QNKKGKKRFL MPFTKQYNHQ RELERSGKVP KFGSYMYSAR
     ALSDKGVLVA WKGMSDYDKI NVTISCDQVG VFVIEGTRGH IQMPGASAVV NIEDLLQAQF
     EAHQFMHLFE GNLKLNVNLL LHLVYKKFYR TQ
//