ID J5K4Q9_9GAMM Unreviewed; 867 AA.
AC J5K4Q9;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Sarcosine dehydrogenase {ECO:0000313|EMBL:EJP71213.1};
GN ORFNames=NT01SARS_1019 {ECO:0000313|EMBL:EJP71213.1};
OS SAR86 cluster bacterium SAR86A.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; SAR86 cluster.
OX NCBI_TaxID=1123866 {ECO:0000313|EMBL:EJP71213.1, ECO:0000313|Proteomes:UP000010305};
RN [1] {ECO:0000313|EMBL:EJP71213.1, ECO:0000313|Proteomes:UP000010305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22170421; DOI=10.1038/ismej.2011.189;
RA Dupont C.L., Rusch D.B., Yooseph S., Lombardo M.J., Richter R.A., Valas R.,
RA Novotny M., Yee-Greenbaum J., Selengut J.D., Haft D.H., Halpern A.L.,
RA Lasken R.S., Nealson K., Friedman R., Venter J.C.;
RT "Genomic insights to SAR86, an abundant and uncultivated marine bacterial
RT lineage.";
RL ISME J. 6:1186-1199(2012).
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DR EMBL; JH611157; EJP71213.1; -; Genomic_DNA.
DR AlphaFoldDB; J5K4Q9; -.
DR STRING; 1123866.NT01SARS_1019; -.
DR HOGENOM; CLU_007884_11_2_6; -.
DR Proteomes; UP000010305; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR032503; FAO_M.
DR InterPro; IPR028896; GCST/YgfZ/DmdA.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR PANTHER; PTHR43757; AMINOMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR43757:SF2; AMINOMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF01266; DAO; 1.
DR Pfam; PF16350; FAO_M; 1.
DR Pfam; PF01571; GCV_T; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010305};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..384
FT /note="FAD dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF01266"
FT DOMAIN 388..441
FT /note="FAD dependent oxidoreductase central"
FT /evidence="ECO:0000259|Pfam:PF16350"
FT DOMAIN 446..734
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
SQ SEQUENCE 867 AA; 96196 MW; A0861A3A9E9BB149 CRC64;
MTDNSNSKFP SEAEVVIVGV GGIVGSMLAY WLAELGQKNI VGLEKSTIIP SDIASTAHAS
DFVYNTTHDK LGCWTTAFSR KFYEDNGFFL KKGGLEICRV GDDERWEELK RKVASGKAFG
TNVSLISAAE AVEKFPLLEE ESMIGAMWDP DAGLVVPRSQ EVVNFAVESA KEKGALKTFT
NTPATDFEIE DGKIVGVKTD KGTIKTNKVV IASGIWGPLM GDKAGVGVPL MPVEHPLLFF
GPYEEIQDTE EMLVYPLLRD QGNSAYVRDT GKFHGGMLEW GYYEDKNPRL VDPEDIGNPD
KTMLSDSMRY LELEEIAEPL EKAFETTPIL SELGWDEKSS FNGLLSVTAD AGSLIGESPE
VRGFWLCEAV WVKDGPGCAR LCAEAMVNGK TQVDMHSFDI SRFYPHQKEK EYVKTRAFEN
SQTIYTPAVH PREPYITQRE MFVSPFYERE KELGGHFENE VAGWERALAY ISNREKLDKY
IKEVPLRENE WDTRHVPYDV ANAEHLAMSD SVGMINLSHF PIMDIKGPDA ERMLEYLSVA
KVGGNTPEGK VIYTNFLDED GGVHADLTIS RLGNDSYRVV TGGADGNRDW VTLRNYRDDN
GLNADINIRT HDIATLGLWG PKAVEALGNF IDPNEIDIKN FPFVSAKNLT LNLSGGKKVH
VWAARISYVG ESGWEIYFNN NKDDGLALYD SLLEVGVVPV GIETYANSRR LEKSFRLQGA
DLETEYTAIE AAIQRPLVKE ADFHGKAAHL AHREEDPCAI LCTMTLDDLN VSGKTRYPVG
ISPIIDPATG EVPIDSKGRR AYTTGMSYCP SLKKFVVMGY LPKEIAIQGK SLLIEYFNED
GDGLYPITVQ IVGKGSLYDP GNERVRA
//
