ID J5W1E7_9FLAO Unreviewed; 773 AA.
AC J5W1E7;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=HMPREF1154_0754 {ECO:0000313|EMBL:EJU34529.1};
OS Capnocytophaga sp. CM59.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Capnocytophaga.
OX NCBI_TaxID=936370 {ECO:0000313|EMBL:EJU34529.1, ECO:0000313|Proteomes:UP000003140};
RN [1] {ECO:0000313|EMBL:EJU34529.1, ECO:0000313|Proteomes:UP000003140}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM59 {ECO:0000313|EMBL:EJU34529.1,
RC ECO:0000313|Proteomes:UP000003140};
RA Durkin A.S., McCorrison J., Torralba M., Gillis M., Methe B., Sutton G.,
RA Nelson K.E.;
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJU34529.1}.
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DR EMBL; ALNN01000004; EJU34529.1; -; Genomic_DNA.
DR RefSeq; WP_009640656.1; NZ_ALNN01000004.1.
DR AlphaFoldDB; J5W1E7; -.
DR PATRIC; fig|936370.3.peg.270; -.
DR Proteomes; UP000003140; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 5..290
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 291..574
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 677..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 26..33
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 773 AA; 89119 MW; 7D480351334B1D70 CRC64;
MNYLDELNEA QRAPVVHKDG PVMVIAGAGS GKTRVLTYRI AYLMQQGVDP FNILALTFTN
KAAREMKERI GRIVGPSEAR NLWMGTFHSV FARILREEAS KLGFPRDFTI YDQQDSHRLI
SAIIKEMGLD KDVYKYKQIA SRISSYKNNL ITVKAYYENP ELQEADAMAK HPRLGDIYRN
YVDRCFKAGA MDFDDLLLRT NELLNVFPEV LAKYQHRFRY ILVDEYQDTN HSQYLIVRAL
ADRFQNICVV GDDAQSIYAF RGANIDNIFN FQKDYRNVGV YRLEQNYRST RNIVEAANNV
IEHNKARLEK VVWTANESGT LIKVHRSPTD ADEGRFVAGT IFEEAMQHQL SYGDFAVLYR
TNMQSRAIED ALRKRDIPYR IYGGLSFYQR KEIKDLLAYF RLAINENDEE ALHRIINFPA
RGIGDTTMER LTLCANEFKL PIFTIIKQLD LMDYGLKING PTRMRLLEFA HMIQSFRIMV
ETHDAFTLAE HIAKRTGILN EFKKDGTPEG IERLQNIEEL LNGIRDFVEG QKEIEEATGS
LAEFLQDVAL ATDLDKEVED DNRVSLMTIH LAKGLEFPYV FIVGMEEDLF PSALSQNTRT
EMEEERRLFY VALTRAEKQA YLTYTESRYR WGKLMDAEPS RFIEEIDERY LEYLTPKDSY
RYRPLINIDA FAPVDKSKLR QQKPTNSPPP AYKKPNEEQL KKLRLQKPEQ AKAVATGDIP
NVAVGNTLLH ERFGKGVVID VEGSGADRKA KVRFENGGEK TLILRFAKFK VIG
//
