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Database: UniProt
Entry: J7IZT4_DESMD
LinkDB: J7IZT4_DESMD
Original site: J7IZT4_DESMD 
ID   J7IZT4_DESMD            Unreviewed;       287 AA.
AC   J7IZT4;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   10-APR-2019, entry version 32.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   OrderedLocusNames=Desmer_2676 {ECO:0000313|EMBL:AFQ44588.1};
OS   Desulfosporosinus meridiei (strain ATCC BAA-275 / DSM 13257 / NCIMB
OS   13706 / S10).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Peptococcaceae;
OC   Desulfosporosinus.
OX   NCBI_TaxID=768704 {ECO:0000313|EMBL:AFQ44588.1, ECO:0000313|Proteomes:UP000005262};
RN   [1] {ECO:0000313|EMBL:AFQ44588.1, ECO:0000313|Proteomes:UP000005262}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-275 / DSM 13257 / NCIMB 13706 / S10
RC   {ECO:0000313|Proteomes:UP000005262};
RX   PubMed=23105050; DOI=10.1128/JB.01392-12;
RA   Pester M., Brambilla E., Alazard D., Rattei T., Weinmaier T., Han J.,
RA   Lucas S., Lapidus A., Cheng J.F., Goodwin L., Pitluck S., Peters L.,
RA   Ovchinnikova G., Teshima H., Detter J.C., Han C.S., Tapia R.,
RA   Land M.L., Hauser L., Kyrpides N.C., Ivanova N.N., Pagani I.,
RA   Huntmann M., Wei C.L., Davenport K.W., Daligault H., Chain P.S.,
RA   Chen A., Mavromatis K., Markowitz V., Szeto E., Mikhailova N.,
RA   Pati A., Wagner M., Woyke T., Ollivier B., Klenk H.P., Spring S.,
RA   Loy A.;
RT   "Complete genome sequences of Desulfosporosinus orientis DSM765T,
RT   Desulfosporosinus youngiae DSM17734T, Desulfosporosinus meridiei
RT   DSM13257T, and Desulfosporosinus acidiphilus DSM22704T.";
RL   J. Bacteriol. 194:6300-6301(2012).
RN   [2] {ECO:0000313|Proteomes:UP000005262}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-275 / DSM 13257 / NCIMB 13706 / S10
RC   {ECO:0000313|Proteomes:UP000005262};
RA   Huntemann M., Wei C.-L., Han J., Detter J.C., Han C., Davenport K.,
RA   Daligault H., Erkkila T., Gu W., Munk A.C.C., Teshima H., Xu Y.,
RA   Chain P., Tapia R., Chen A., Krypides N., Mavromatis K., Markowitz V.,
RA   Szeto E., Ivanova N., Mikhailova N., Ovchinnikova G., Pagani I.,
RA   Pati A., Goodwin L., Peters L., Pitluck S., Woyke T., Pester M.,
RA   Spring S., Ollivier B., Rattei T., Klenk H.-P., Wagner M., Loy A.;
RT   "Finished genome of Desulfosporosinus meridiei DSM 13257.";
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
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DR   EMBL; CP003629; AFQ44588.1; -; Genomic_DNA.
DR   RefSeq; WP_014903501.1; NC_018515.1.
DR   STRING; 768704.Desmer_2676; -.
DR   EnsemblBacteria; AFQ44588; AFQ44588; Desmer_2676.
DR   KEGG; dmi:Desmer_2676; -.
DR   KO; K04518; -.
DR   OMA; REVMSAC; -.
DR   OrthoDB; 1280729at2; -.
DR   BioCyc; DMER768704:G1H10-2605-MONOMER; -.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000005262; Chromosome.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00857; PREPHENATE_DEHYDR_1; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005262};
KW   Lyase {ECO:0000256|RuleBase:RU361254, ECO:0000313|EMBL:AFQ44588.1};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005262}.
FT   DOMAIN        3    188       Prephenate dehydratase.
FT                                {ECO:0000259|PROSITE:PS51171}.
FT   DOMAIN      201    278       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   SITE        181    181       Essential for prephenate dehydratase
FT                                activity. {ECO:0000256|PIRSR:PIRSR001500-
FT                                2}.
SQ   SEQUENCE   287 AA;  32388 MW;  E2F53CB7B52F4D2D CRC64;
     MQKIGFLGPK GSFSEEAILL FLATHPDLTA TAPDLIPFST IPKLLFACND HEIDWAFVPL
     ENSTEGQVGV TMDTLGQTEH LFITHEFIHP IDQCLLAHES MPLEQIERIY SHEQAIGQCR
     DFLENYLPNA QQITCLSTAE AAHRISSIRE NWAAIGPRRA ARLYNLHILK ECIQDATLNA
     TRFVMVGHNL AEMSDGEDKT SLLVIAENTP GSLYRILGEF AKRQINLSRI ESRPSKRILG
     EYVFFVDVDG YVFAPPIQDV LWAFKEEHIS VKLLGSYPKA HPQERTF
//
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