ID J7JGR6_BIOGL Unreviewed; 224 AA.
AC J7JGR6;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Acetylcholine-binding protein type 2 {ECO:0000313|EMBL:AFQ55391.1, ECO:0000313|EnsemblMetazoa:BGLB020983-PA};
GN Name=AChBP2 {ECO:0000313|EMBL:AFQ55391.1};
GN Synonyms=106055630 {ECO:0000313|EnsemblMetazoa:BGLB020983-PA};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EMBL:AFQ55391.1, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EMBL:AFQ55391.1, ECO:0007829|PDB:4AOE}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22916297; DOI=10.1371/JOURNAL.PONE.0043685;
RA Saur M., Moeller V., Kapetanopoulos K., Braukmann S., Gebauer W.,
RA Tenzer S., Markl J.;
RT "Acetylcholine-binding protein in the hemolymph of the planorbid snail
RT Biomphalaria glabrata is a pentagonal dodecahedron (60 subunits).";
RL PLoS ONE 7:e43685-e43685(2012).
RN [2] {ECO:0000313|EnsemblMetazoa:BGLB020983-PB}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB020983-PA};
RG EnsemblMetazoa;
RL Submitted (JAN-2021) to UniProtKB.
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DR EMBL; JQ814368; AFQ55391.1; -; Genomic_DNA.
DR RefSeq; XP_013067424.1; XM_013211970.1.
DR RefSeq; XP_013067425.1; XM_013211971.1.
DR PDB; 4AOE; EM; 5.80 A; A/B/C/D/E=20-224.
DR PDBsum; 4AOE; -.
DR AlphaFoldDB; J7JGR6; -.
DR SMR; J7JGR6; -.
DR STRING; 6526.J7JGR6; -.
DR EnsemblMetazoa; BGLB020983-RA; BGLB020983-PA; BGLB020983.
DR EnsemblMetazoa; BGLB020983-RB; BGLB020983-PB; BGLB020983.
DR GeneID; 106055630; -.
DR KEGG; bgt:106055630; -.
DR VEuPathDB; VectorBase:BGLB020983; -.
DR OrthoDB; 2938410at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18995; LGIC_AChBP; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR PANTHER; PTHR18945:SF865; ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 2; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:4AOE}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..224
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011942403"
FT DOMAIN 25..222
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DISULFID 145..158
FT /evidence="ECO:0007829|PDB:4AOE"
FT DISULFID 207..208
FT /evidence="ECO:0007829|PDB:4AOE"
SQ SEQUENCE 224 AA; 25550 MW; 6DBC9A289B16E24A CRC64;
MDSLKVVLIV CLLIYGSHGT KKSREEIVKE ILGRANPNNI PIVDEQPVKV SFKYSLQDIY
TADVGTDQVE LGLWLVISWK DRSLSWSNEC TTFNELTLPS KYIWLPHIEV YNSIGKPGIH
SDQLVRVYKD GTVTFVPQYT IRFSCALENV TTEQGAACTL KFGPWTYDVR DLVLDESQQV
DLTTYAGGER FQLIEAKQKV NKKTYPCCPQ SFEDIELRVT FKKI
//
